Assay Detail
Binding
CHEMBL4629259
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of rat bone marrow myeloperoxidase using H2O2 as substrate after 20 mins by TMB based method
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Acylhydrazones as isoniazid derivatives with multi-target profiles for the treatment of Alzheimer's disease: Radical scavenging, myeloperoxidase/acetylcholinesterase inhibition and biometal chelation.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 8 | 5.51 | 5.85 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1945275 | N'-(4-DIMETHYLAMINOBENZYLIDENE)ISONICOTINOHYDRAZIDE | — | 1 | 5.85 |
| CHEMBL2236631 | — | — | 1 | 5.82 |
| CHEMBL64 | ISONIAZID | 4.0 | 1 | 5.41 |
| CHEMBL199405 | — | — | 1 | 5.37 |
| CHEMBL199452 | — | — | 1 | 5.32 |
| CHEMBL3212643 | — | — | 1 | 5.28 |
| CHEMBL50 | QUERCETIN | 3.0 | 1 | - |
| CHEMBL2105120 | FTIVAZIDE | 2.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1945275 | N'-(4-DIMETHYLAMINOBENZYLIDENE)ISONICOTINOHYDRAZIDE | IC50 | = | 1400.0 | nM | 5.85 |
| CHEMBL2236631 | — | IC50 | = | 1500.0 | nM | 5.82 |
| CHEMBL64 | ISONIAZID | IC50 | = | 3900.0 | nM | 5.41 |
| CHEMBL199405 | — | IC50 | = | 4300.0 | nM | 5.37 |
| CHEMBL199452 | — | IC50 | = | 4800.0 | nM | 5.32 |
| CHEMBL3212643 | — | IC50 | = | 5300.0 | nM | 5.28 |
| CHEMBL50 | QUERCETIN | IC50 | - | — | - | |
| CHEMBL2105120 | FTIVAZIDE | IC50 | - | — | - |