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Compound Detail

CHEMBL3212643

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O=C(N/N=C/c1coc2ccccc2c1=O)c1ccncc1

Basic Information

ChEMBL ID CHEMBL3212643
Phase Preclinical
Structure Type MOL
InChI Key YFNDGAPTSYRUMC-GIJQJNRQSA-N
2
Targets
2
Activities
1
Assay Types
0
PK Parameters
3
Publications
0
Known Names

Molecular Properties

293.3
MW (Da)
1.95
ALogP
5
HBA
1
HBD
84.6
PSA (Ų)
0.59
QED
0
Ro5 Violations
3
Rot. Bonds

Drug Information

Molecule Type Small molecule
Availability Unknown
Chirality Unknown

Flags

First in Class Prodrug

Extended Properties

Molecular Formula C16H11N3O3
MW 293.28
Aromatic Rings 3
Heavy Atoms 22
NP-Likeness -1.28

Activity Summary

IC50 2 meas. best 5.28

Target Activity Profile

Target Type Best pChEMBL Mean pChEMBL Best (nM) # Data
Unchecked
CHEMBL612545
IC50 5.28 5.28 5300.0 1
No relevant target
CHEMBL2362975
IC50 4.37 4.37 42400.0 1

Activity Data Samples

Top measurements by pChEMBL value

Literature References

PubMed DOI Target Context # Activities
32278712 10.1016/j.bmc.2020.115470 No relevant target 9
32278712 10.1016/j.bmc.2020.115470 Unchecked 2
32278712 10.1016/j.bmc.2020.115470 Acetylcholinesterase 2

Data from ChEMBL 36 via Core Engine