Assay Detail
Binding
CHEMBL4629880
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of human MEK5 using ERK5 as substrate in presence of [gamma-33P]-ATP by hotspot kinase assay
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Dual specificity mitogen-activated protein kinase kinase 5 (CHEMBL4948) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Discovery of Highly Selective Inhibitors of Calmodulin-Dependent Kinases That Restore Insulin Sensitivity in the Diet-Induced Obesity <i>in Vivo</i> Mouse Model.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 6.45 | 7.60 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4635883 | — | — | 1 | 7.60 |
| CHEMBL1835063 | — | — | 1 | 6.62 |
| CHEMBL4640712 | — | — | 1 | 5.12 |
| CHEMBL4648967 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4635883 | — | IC50 | = | 25.0 | nM | 7.60 |
| CHEMBL1835063 | — | IC50 | = | 240.0 | nM | 6.62 |
| CHEMBL4640712 | — | IC50 | = | 7680.0 | nM | 5.12 |
| CHEMBL4648967 | — | IC50 | > | 10000.0 | nM | - |