Assay Detail
Functional
CHEMBL4666427
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antiproliferative activity against human MV4-11 cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay
13
Total Activities
13
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | MV4-11 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Design, synthesis and biological evaluation of pyridone-aminal derivatives as MNK1/2 inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 13 | 4.91 | 5.02 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4796087 | — | — | 1 | 5.02 |
| CHEMBL4757546 | — | — | 1 | 5.00 |
| CHEMBL4754824 | — | — | 1 | 4.96 |
| CHEMBL4760245 | — | — | 1 | 4.88 |
| CHEMBL4073443 | TOMIVOSERTIB | 2.0 | 1 | 4.84 |
| CHEMBL4793971 | — | — | 1 | 4.73 |
| CHEMBL4780209 | — | — | 1 | - |
| CHEMBL4751127 | — | — | 1 | - |
| CHEMBL4740694 | — | — | 1 | - |
| CHEMBL4784364 | — | — | 1 | - |
| CHEMBL4797669 | — | — | 1 | - |
| CHEMBL4787265 | — | — | 1 | - |
| CHEMBL4741081 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4796087 | — | IC50 | = | 9640.0 | nM | 5.02 |
| CHEMBL4757546 | — | IC50 | = | 10030.0 | nM | 5.00 |
| CHEMBL4754824 | — | IC50 | = | 11040.0 | nM | 4.96 |
| CHEMBL4760245 | — | IC50 | = | 13260.0 | nM | 4.88 |
| CHEMBL4073443 | TOMIVOSERTIB | IC50 | = | 14490.0 | nM | 4.84 |
| CHEMBL4793971 | — | IC50 | = | 18490.0 | nM | 4.73 |
| CHEMBL4780209 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL4751127 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL4740694 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL4784364 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL4797669 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL4787265 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL4741081 | — | IC50 | > | 20000.0 | nM | - |