Compound Detail
CHEMBL4796087
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Basic Information
| ChEMBL ID | CHEMBL4796087 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | VENBOQULCZPZRI-UHFFFAOYSA-N |
5
Targets
5
Activities
1
Assay Types
0
PK Parameters
9
Publications
0
Known Names
Molecular Properties
480.6
MW (Da)
1.73
ALogP
9
HBA
2
HBD
98.6
PSA (Ų)
0.65
QED
0
Ro5 Violations
6
Rot. Bonds
Drug Information
| Molecule Type | Unknown |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 5 meas. best 8.12
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| MAP kinase-interacting serine/threonine-protein kinase 2 CHEMBL4204 | IC50 | 8.12 | 8.12 | 7.5 | 1 |
| MAP kinase-interacting serine/threonine-protein kinase 1 CHEMBL4718 | IC50 | 8.06 | 8.06 | 8.7 | 1 |
| TMD8 CHEMBL4296503 | IC50 | 5.72 | 5.72 | 1920.0 | 1 |
| MV4-11 CHEMBL613835 | IC50 | 5.02 | 5.02 | 9640.0 | 1 |
| K562 CHEMBL385 | IC50 | 4.88 | 4.88 | 13040.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| MAP kinase-interacting serine/threonine-protein kinase 2 | IC50 | = | 7.5 | nM | 8.12 | Inhibition of recombinant human N-terminal GST-tagged MNK2 (1 to 465 residues) e... | 30824167 |
| MAP kinase-interacting serine/threonine-protein kinase 1 | IC50 | = | 8.7 | nM | 8.06 | Inhibition of recombinant human N-terminal DYKDDDDK-tagged MNK1(1 to 424 residue... | 30824167 |
| TMD8 | IC50 | = | 1920.0 | nM | 5.72 | Antiproliferative activity against human TMD8 cells assessed as reduction in cel... | 30824167 |
| MV4-11 | IC50 | = | 9640.0 | nM | 5.02 | Antiproliferative activity against human MV4-11 cells assessed as reduction in c... | 30824167 |
| K562 | IC50 | = | 13040.0 | nM | 4.88 | Antiproliferative activity against human K562 cells assessed as reduction in cel... | 30824167 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 30824167 | 10.1016/j.bmc.2019.02.007 | MAP kinase-interacting serine/threonine-protein kinase 1 | 3 |
| 30824167 | 10.1016/j.bmc.2019.02.007 | MAP kinase-interacting serine/threonine-protein kinase 2 | 3 |
| 30824167 | 10.1016/j.bmc.2019.02.007 | Unchecked | 1 |
| 30824167 | 10.1016/j.bmc.2019.02.007 | MDA-MB-435 | 1 |
| 30824167 | 10.1016/j.bmc.2019.02.007 | HCT-116 | 1 |
| 30824167 | 10.1016/j.bmc.2019.02.007 | A549 | 1 |
| 30824167 | 10.1016/j.bmc.2019.02.007 | TMD8 | 1 |
| 30824167 | 10.1016/j.bmc.2019.02.007 | K562 | 1 |
| 30824167 | 10.1016/j.bmc.2019.02.007 | MV4-11 | 1 |
Data from ChEMBL 36 via Core Engine