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Assay Detail

CHEMBL4667669

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Inhibition of MALT1 (unknown origin) by Glosensor reporter gene assay
28
Total Activities
28
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Homo sapiens
Confidence 9 — Direct single protein target
Curated By Autocuration

Publication

Quinoline and thiazolopyridine allosteric inhibitors of MALT1.
Scott DA,Hatcher JM,Liu H,Fu M,Du G,Fontán L,Us I,Casalena G,Qiao Q,Wu H,Melnick A,Gray NS
Bioorg Med Chem Lett (2019) 29 : 1694 -1698
PubMed 31129051 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 28 7.18 8.70

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL4784740 1 8.70
CHEMBL4748253 1 8.22
CHEMBL4741853 1 8.22
CHEMBL4779581 1 8.15
CHEMBL4762086 1 8.15
CHEMBL4740000 1 7.89
CHEMBL4791759 1 7.75
CHEMBL4749826 1 7.57
CHEMBL4751498 1 7.55
CHEMBL4749854 1 7.52
CHEMBL4790415 1 7.48
CHEMBL4789469 1 7.46
CHEMBL4784899 1 7.44
CHEMBL4794268 1 7.34
CHEMBL4763765 1 7.26
CHEMBL4788571 1 7.16
CHEMBL4742156 1 7.11
CHEMBL4740768 1 7.04
CHEMBL4759864 1 6.80
CHEMBL4755479 1 6.78
CHEMBL4782908 1 6.62
CHEMBL4784606 1 6.37
CHEMBL4760252 1 6.35
CHEMBL4783451 1 5.70
CHEMBL4799622 1 5.22
CHEMBL4777911 1 4.71
CHEMBL4780316 1 -
CHEMBL4751202 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL4784740 IC50 = 2.0 nM 8.70
CHEMBL4748253 IC50 = 6.0 nM 8.22
CHEMBL4741853 IC50 = 6.0 nM 8.22
CHEMBL4779581 IC50 = 7.0 nM 8.15
CHEMBL4762086 IC50 = 7.0 nM 8.15
CHEMBL4740000 IC50 = 13.0 nM 7.89
CHEMBL4791759 IC50 = 18.0 nM 7.75
CHEMBL4749826 IC50 = 27.0 nM 7.57
CHEMBL4751498 IC50 = 28.0 nM 7.55
CHEMBL4749854 IC50 = 30.0 nM 7.52
CHEMBL4790415 IC50 = 33.0 nM 7.48
CHEMBL4789469 IC50 = 35.0 nM 7.46
CHEMBL4784899 IC50 = 36.0 nM 7.44
CHEMBL4794268 IC50 = 46.0 nM 7.34
CHEMBL4763765 IC50 = 55.0 nM 7.26
CHEMBL4788571 IC50 = 69.0 nM 7.16
CHEMBL4742156 IC50 = 78.0 nM 7.11
CHEMBL4740768 IC50 = 92.0 nM 7.04
CHEMBL4759864 IC50 = 160.0 nM 6.80
CHEMBL4755479 IC50 = 165.0 nM 6.78
CHEMBL4782908 IC50 = 237.0 nM 6.62
CHEMBL4784606 IC50 = 432.0 nM 6.37
CHEMBL4760252 IC50 = 451.0 nM 6.35
CHEMBL4783451 IC50 = 1980.0 nM 5.70
CHEMBL4799622 IC50 = 6020.0 nM 5.22
CHEMBL4777911 IC50 = 19300.0 nM 4.71
CHEMBL4780316 IC50 > 20000.0 nM -
CHEMBL4751202 IC50 > 20000.0 nM -