Assay Detail
Binding
CHEMBL4667705
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Binding affinity to human wild type partial length non-phosphorylated ABL1 (S229 to K512 residues) expressed in mammalian expression system by Kinomescan method
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Utilizing comprehensive and mini-kinome panels to optimize the selectivity of quinoline inhibitors for cyclin G associated kinase (GAK).
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Kd | 3 | 6.14 | 6.77 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL311959 | — | — | 1 | 6.77 |
| CHEMBL4443342 | — | — | 1 | 5.92 |
| CHEMBL535429 | — | — | 1 | 5.72 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL311959 | — | Kd | = | 170.0 | nM | 6.77 |
| CHEMBL4443342 | — | Kd | = | 1200.0 | nM | 5.92 |
| CHEMBL535429 | — | Kd | = | 1900.0 | nM | 5.72 |