Assay Detail
Binding
CHEMBL4667712
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Binding affinity to human wild type partial length EphB6 (Q634 to P948 residues) expressed in mammalian expression system by Kinomescan method
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Utilizing comprehensive and mini-kinome panels to optimize the selectivity of quinoline inhibitors for cyclin G associated kinase (GAK).
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Kd | 3 | 6.28 | 6.89 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL311959 | — | — | 1 | 6.89 |
| CHEMBL4443342 | — | — | 1 | 6.15 |
| CHEMBL535429 | — | — | 1 | 5.80 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL311959 | — | Kd | = | 130.0 | nM | 6.89 |
| CHEMBL4443342 | — | Kd | = | 710.0 | nM | 6.15 |
| CHEMBL535429 | — | Kd | = | 1600.0 | nM | 5.80 |