Assay Detail
Binding
CHEMBL4667723
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Binding affinity to GAK (unknown origin)
3
Total Activities
3
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Utilizing comprehensive and mini-kinome panels to optimize the selectivity of quinoline inhibitors for cyclin G associated kinase (GAK).
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Kd | 2 | 7.53 | 7.54 |
| Ki | 1 | 8.82 | 8.82 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4797973 | — | — | 1 | 8.82 |
| CHEMBL29197 | — | — | 1 | 7.54 |
| CHEMBL535429 | — | — | 1 | 7.51 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4797973 | — | Ki | = | 1.5 | nM | 8.82 |
| CHEMBL29197 | — | Kd | = | 29.0 | nM | 7.54 |
| CHEMBL535429 | — | Kd | = | 31.0 | nM | 7.51 |