Assay Detail
Functional
CHEMBL4667770
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Antiproliferative activity against human HL-60 cells after 72 hrs by MTT assay
40
Total Activities
40
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | HL-60 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Design, synthesis, and biological activity evaluation of (-)-6-O-desmethylantofine analogues as potent anti-cancer agents.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 40 | 6.59 | 8.40 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL484042 | — | — | 1 | 8.40 |
| CHEMBL4743449 | — | — | 1 | 7.60 |
| CHEMBL4743289 | — | — | 1 | 7.36 |
| CHEMBL2289201 | — | — | 1 | 7.36 |
| CHEMBL1958054 | — | — | 1 | 7.30 |
| CHEMBL4763235 | — | — | 1 | 7.25 |
| CHEMBL4760857 | — | — | 1 | 7.18 |
| CHEMBL2289194 | — | — | 1 | 7.09 |
| CHEMBL4750897 | — | — | 1 | 6.97 |
| CHEMBL4755155 | — | — | 1 | 6.95 |
| CHEMBL4744010 | — | — | 1 | 6.82 |
| CHEMBL4791591 | — | — | 1 | 6.75 |
| CHEMBL4740398 | — | — | 1 | 6.75 |
| CHEMBL4758869 | — | — | 1 | 6.74 |
| CHEMBL399454 | — | — | 1 | 6.67 |
| CHEMBL2289195 | — | — | 1 | 6.66 |
| CHEMBL4749706 | — | — | 1 | 6.66 |
| CHEMBL4750373 | — | — | 1 | 6.64 |
| CHEMBL4740816 | — | — | 1 | 6.63 |
| CHEMBL4786180 | — | — | 1 | 6.61 |
| CHEMBL2289202 | — | — | 1 | 6.52 |
| CHEMBL4795617 | — | — | 1 | 6.42 |
| CHEMBL4743634 | — | — | 1 | 6.34 |
| CHEMBL4753221 | — | — | 1 | 6.33 |
| CHEMBL4782431 | — | — | 1 | 6.31 |
| CHEMBL4799733 | — | — | 1 | 6.30 |
| CHEMBL4777506 | — | — | 1 | 6.25 |
| CHEMBL4764197 | — | — | 1 | 6.24 |
| CHEMBL4776953 | — | — | 1 | 6.22 |
| CHEMBL4784770 | — | — | 1 | 6.21 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL484042 | — | IC50 | = | 4.0 | nM | 8.40 |
| CHEMBL4743449 | — | IC50 | = | 25.0 | nM | 7.60 |
| CHEMBL2289201 | — | IC50 | = | 44.0 | nM | 7.36 |
| CHEMBL4743289 | — | IC50 | = | 44.0 | nM | 7.36 |
| CHEMBL1958054 | — | IC50 | = | 50.0 | nM | 7.30 |
| CHEMBL4763235 | — | IC50 | = | 56.0 | nM | 7.25 |
| CHEMBL4760857 | — | IC50 | = | 66.0 | nM | 7.18 |
| CHEMBL2289194 | — | IC50 | = | 81.0 | nM | 7.09 |
| CHEMBL4750897 | — | IC50 | = | 106.0 | nM | 6.97 |
| CHEMBL4755155 | — | IC50 | = | 112.0 | nM | 6.95 |
| CHEMBL4744010 | — | IC50 | = | 153.0 | nM | 6.82 |
| CHEMBL4791591 | — | IC50 | = | 178.0 | nM | 6.75 |
| CHEMBL4740398 | — | IC50 | = | 179.0 | nM | 6.75 |
| CHEMBL4758869 | — | IC50 | = | 181.0 | nM | 6.74 |
| CHEMBL399454 | — | IC50 | = | 213.0 | nM | 6.67 |
| CHEMBL2289195 | — | IC50 | = | 220.0 | nM | 6.66 |
| CHEMBL4749706 | — | IC50 | = | 219.0 | nM | 6.66 |
| CHEMBL4750373 | — | IC50 | = | 227.0 | nM | 6.64 |
| CHEMBL4740816 | — | IC50 | = | 233.0 | nM | 6.63 |
| CHEMBL4786180 | — | IC50 | = | 245.0 | nM | 6.61 |
| CHEMBL2289202 | — | IC50 | = | 301.0 | nM | 6.52 |
| CHEMBL4795617 | — | IC50 | = | 379.0 | nM | 6.42 |
| CHEMBL4743634 | — | IC50 | = | 455.0 | nM | 6.34 |
| CHEMBL4753221 | — | IC50 | = | 472.0 | nM | 6.33 |
| CHEMBL4782431 | — | IC50 | = | 494.0 | nM | 6.31 |
| CHEMBL4799733 | — | IC50 | = | 505.0 | nM | 6.30 |
| CHEMBL4777506 | — | IC50 | = | 568.0 | nM | 6.25 |
| CHEMBL4764197 | — | IC50 | = | 580.0 | nM | 6.24 |
| CHEMBL4776953 | — | IC50 | = | 600.0 | nM | 6.22 |
| CHEMBL4784770 | — | IC50 | = | 611.0 | nM | 6.21 |
| CHEMBL4746173 | — | IC50 | = | 674.0 | nM | 6.17 |
| CHEMBL4797990 | — | IC50 | = | 683.0 | nM | 6.17 |
| CHEMBL2289196 | — | IC50 | = | 756.0 | nM | 6.12 |
| CHEMBL4754412 | — | IC50 | = | 762.0 | nM | 6.12 |
| CHEMBL4749199 | — | IC50 | = | 800.0 | nM | 6.10 |
| CHEMBL4795836 | — | IC50 | = | 908.0 | nM | 6.04 |
| CHEMBL4755267 | — | IC50 | = | 1080.0 | nM | 5.97 |
| CHEMBL4787027 | — | IC50 | = | 2832.0 | nM | 5.55 |
| CHEMBL4800471 | — | IC50 | = | 7800.0 | nM | 5.11 |
| CHEMBL4744712 | — | IC50 | > | 10000.0 | nM | - |