Assay Detail
Functional
CHEMBL4668028
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Trypanocidal activity activity against Trypanosoma brucei rhodesiense STI B900 assessed as reduction in parasite viability
15
Total Activities
15
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Trypanosoma brucei rhodesiense |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Target
Trypanosoma brucei rhodesiense (CHEMBL612348) ↗| Type | ORGANISM |
| Organism | Trypanosoma brucei rhodesiense |
Publication
Discovery and characterization of trypanocidal cysteine protease inhibitors from the 'malaria box'.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 15 | 5.17 | 7.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4793916 | — | — | 1 | 7.00 |
| CHEMBL531738 | — | — | 1 | 6.40 |
| CHEMBL527730 | — | — | 1 | 6.40 |
| CHEMBL580140 | — | — | 1 | 5.89 |
| CHEMBL597248 | — | — | 1 | 5.51 |
| CHEMBL2028048 | — | — | 1 | 4.97 |
| CHEMBL546168 | — | — | 1 | 4.80 |
| CHEMBL602552 | — | — | 1 | 4.79 |
| CHEMBL533921 | — | — | 1 | 4.79 |
| CHEMBL591128 | — | — | 1 | 4.52 |
| CHEMBL527541 | — | — | 1 | 4.50 |
| CHEMBL529603 | — | — | 1 | 4.50 |
| CHEMBL582420 | — | — | 1 | 4.50 |
| CHEMBL532015 | — | — | 1 | 4.50 |
| CHEMBL529874 | — | — | 1 | 4.50 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4793916 | — | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL531738 | — | IC50 | = | 400.0 | nM | 6.40 |
| CHEMBL527730 | — | IC50 | = | 400.0 | nM | 6.40 |
| CHEMBL580140 | — | IC50 | = | 1300.0 | nM | 5.89 |
| CHEMBL597248 | — | IC50 | = | 3100.0 | nM | 5.51 |
| CHEMBL2028048 | — | IC50 | = | 10800.0 | nM | 4.97 |
| CHEMBL546168 | — | IC50 | = | 15900.0 | nM | 4.80 |
| CHEMBL602552 | — | IC50 | = | 16100.0 | nM | 4.79 |
| CHEMBL533921 | — | IC50 | = | 16100.0 | nM | 4.79 |
| CHEMBL591128 | — | IC50 | = | 30500.0 | nM | 4.52 |
| CHEMBL527541 | — | IC50 | = | 32000.0 | nM | 4.50 |
| CHEMBL529603 | — | IC50 | = | 32000.0 | nM | 4.50 |
| CHEMBL582420 | — | IC50 | = | 32000.0 | nM | 4.50 |
| CHEMBL532015 | — | IC50 | = | 32000.0 | nM | 4.50 |
| CHEMBL529874 | — | IC50 | = | 32000.0 | nM | 4.50 |