Assay Detail
Binding
CHEMBL4668246
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of BMX (unknown origin)
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Cytoplasmic tyrosine-protein kinase BMX (CHEMBL3834) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Design of Potent and Selective Covalent Inhibitors of Bruton's Tyrosine Kinase Targeting an Inactive Conformation.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 6.20 | 9.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1873475 | IBRUTINIB | 4.0 | 1 | 9.00 |
| CHEMBL4762397 | — | — | 1 | 5.30 |
| CHEMBL4795673 | — | — | 1 | 4.31 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1873475 | IBRUTINIB | IC50 | = | 1.0 | nM | 9.00 |
| CHEMBL4762397 | — | IC50 | = | 5000.0 | nM | 5.30 |
| CHEMBL4795673 | — | IC50 | = | 49000.0 | nM | 4.31 |