Assay Detail
Binding
CHEMBL4668410
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of tubulin polymerization (unknown origin) incubated for 20 mins
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 5 — Multiple protein complex / RNA |
| Curated By | Autocuration |
Publication
Colchicine Alkaloids and Synthetic Analogues: Current Progress and Perspectives.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 7 | 5.90 | 6.19 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL18981 | THIOCOLCHICINE | — | 1 | 6.19 |
| CHEMBL368737 | THIOCOLCHICONE | — | 1 | 6.12 |
| CHEMBL427472 | — | — | 1 | 6.12 |
| CHEMBL172557 | — | — | 1 | 5.92 |
| CHEMBL298240 | — | — | 1 | 5.89 |
| CHEMBL107 | COLCHICINE | 4.0 | 1 | 5.82 |
| CHEMBL176684 | — | — | 1 | 5.21 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL18981 | THIOCOLCHICINE | IC50 | = | 650.0 | nM | 6.19 |
| CHEMBL368737 | THIOCOLCHICONE | IC50 | = | 760.0 | nM | 6.12 |
| CHEMBL427472 | — | IC50 | = | 750.0 | nM | 6.12 |
| CHEMBL172557 | — | IC50 | = | 1200.0 | nM | 5.92 |
| CHEMBL298240 | — | IC50 | = | 1300.0 | nM | 5.89 |
| CHEMBL107 | COLCHICINE | IC50 | = | 1500.0 | nM | 5.82 |
| CHEMBL176684 | — | IC50 | = | 6200.0 | nM | 5.21 |