Assay Detail
Binding
CHEMBL4668457
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Binding affinity to N-terminal MBP-fused C-terminal His6 tagged-PPP1R15A (340 to 698 residues) (unknown origin) expressed in Escherichia coli BL21-Gold (DE3) pLysS/N-terminal biotinylated human PPP1CC (1 to 322 residues) expressed in baculovirus infected sf9 cells measured after 3 mins by surface plasmon resonance method
1
Total Activities
1
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Recent Advances of SHP2 Inhibitors in Cancer Therapy: Current Development and Clinical Application.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Kd | 1 | 4.64 | 4.64 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2365743 | — | — | 1 | 4.64 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2365743 | — | Kd | = | 23000.0 | nM | 4.64 |