Assay Detail
Binding
CHEMBL4668490
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of PTP1B (unknown origin) using 6,8-difluoro-4-methylum-belliferylphosphate as substrate preincubated for 1 hr followed by substrate by fluorescence method
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Tyrosine-protein phosphatase non-receptor type 1 (CHEMBL335) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Recent Advances of SHP2 Inhibitors in Cancer Therapy: Current Development and Clinical Application.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 5.17 | 5.50 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4762771 | — | — | 1 | 5.50 |
| CHEMBL4784105 | — | — | 1 | 5.18 |
| CHEMBL4780471 | — | — | 1 | 5.17 |
| CHEMBL4746515 | — | — | 1 | 5.05 |
| CHEMBL4750975 | — | — | 1 | 4.97 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4762771 | — | IC50 | = | 3170.0 | nM | 5.50 |
| CHEMBL4784105 | — | IC50 | = | 6560.0 | nM | 5.18 |
| CHEMBL4780471 | — | IC50 | = | 6800.0 | nM | 5.17 |
| CHEMBL4746515 | — | IC50 | = | 8930.0 | nM | 5.05 |
| CHEMBL4750975 | — | IC50 | = | 10600.0 | nM | 4.97 |