Assay Detail
Binding
CHEMBL4668506
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of human AKR1C3 using S-tetralol as substrate in presence of NADP by fluorescence method
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Aldo-keto reductase family 1 member C3 (CHEMBL4681) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Overview of AKR1C3: Inhibitor Achievements and Disease Insights.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 7.23 | 7.46 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4439327 | — | — | 1 | 7.46 |
| CHEMBL4758386 | — | — | 1 | 7.28 |
| CHEMBL4795494 | — | — | 1 | 7.09 |
| CHEMBL2023820 | — | — | 1 | 7.07 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4439327 | — | IC50 | = | 35.0 | nM | 7.46 |
| CHEMBL4758386 | — | IC50 | = | 53.0 | nM | 7.28 |
| CHEMBL4795494 | — | IC50 | = | 82.0 | nM | 7.09 |
| CHEMBL2023820 | — | IC50 | = | 86.0 | nM | 7.07 |