Assay Detail
Binding
CHEMBL4668523
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of human AKR1C3 expressed in Escherichia coli BL21(DE3) pLysS cells using 9,10-phenanthrenequinone as substrate
2
Total Activities
2
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Aldo-keto reductase family 1 member C3 (CHEMBL4681) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Overview of AKR1C3: Inhibitor Achievements and Disease Insights.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 2 | 6.12 | 6.16 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL267476 | LINOLEIC ACID | 2.0 | 1 | 6.16 |
| CHEMBL267484 | — | — | 1 | 6.08 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL267476 | LINOLEIC ACID | IC50 | = | 690.0 | nM | 6.16 |
| CHEMBL267484 | — | IC50 | = | 840.0 | nM | 6.08 |