Assay Detail
Binding
CHEMBL4668615
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Binding affinity to N-terminal GST-fused human PTP1B (1 to 288 residues) expressed in Escherichia coli BL21(DE3) by HSQC NMR analysis
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Tyrosine-protein phosphatase non-receptor type 1 (CHEMBL335) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Fragment Linking Strategies for Structure-Based Drug Design.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Kd | 4 | 3.34 | 4.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL65459 | — | — | 1 | 4.00 |
| CHEMBL115406 | — | — | 1 | 3.10 |
| CHEMBL1169 | AMINOSALICYLIC ACID | 4.0 | 1 | 2.92 |
| CHEMBL1160559 | QUINALDIC ACID | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL65459 | — | Kd | = | 100000.0 | nM | 4.00 |
| CHEMBL115406 | — | Kd | = | 800000.0 | nM | 3.10 |
| CHEMBL1169 | AMINOSALICYLIC ACID | Kd | = | 1200000.0 | nM | 2.92 |
| CHEMBL1160559 | QUINALDIC ACID | Kd | > | 1000000.0 | nM | - |