Assay Detail
Binding
CHEMBL4668801
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Displacement of [3H]-CP-55,940 from recombinant human CB2R expressed in HEK293 cell membranes after 90 mins
10
Total Activities
5
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | HEK293 |
| Subcellular | Cell membrane |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Synthesis of the Major Mammalian Metabolites of THCV.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 6.70 | 7.75 |
| Ki | 5 | 7.50 | 8.55 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2387541 | TETRAHYDROCANNABIVARIN | 2.0 | 2 | 8.55 |
| CHEMBL4747195 | — | — | 2 | 8.33 |
| CHEMBL4760215 | — | — | 2 | 6.89 |
| CHEMBL4747880 | — | — | 2 | 6.23 |
| CHEMBL4763058 | — | — | 2 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2387541 | TETRAHYDROCANNABIVARIN | Ki | = | 2.8 | nM | 8.55 |
| CHEMBL4747195 | — | Ki | = | 4.7 | nM | 8.33 |
| CHEMBL2387541 | TETRAHYDROCANNABIVARIN | IC50 | = | 17.6 | nM | 7.75 |
| CHEMBL4747195 | — | IC50 | = | 29.8 | nM | 7.53 |
| CHEMBL4760215 | — | Ki | = | 128.2 | nM | 6.89 |
| CHEMBL4747880 | — | Ki | = | 589.7 | nM | 6.23 |
| CHEMBL4760215 | — | IC50 | = | 807.7 | nM | 6.09 |
| CHEMBL4747880 | — | IC50 | = | 3715.0 | nM | 5.43 |
| CHEMBL4763058 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL4763058 | — | Ki | > | 10000.0 | nM | - |