Assay Detail
Functional
CHEMBL4668822
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Cytotoxicity against human CCRF-CEM cells assessed as reduction in cell viability after 72 hrs by resazurin dye-based fluorescence assay
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | CCRF-CEM |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Cytotoxic Bufadienolides from the Leaves of Melianthus major.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 7 | 6.50 | 7.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL53463 | DOXORUBICIN | 4.0 | 1 | 7.70 |
| CHEMBL4764669 | — | — | 1 | 7.00 |
| CHEMBL4758181 | — | — | 1 | 6.70 |
| CHEMBL4800153 | — | — | 1 | 6.30 |
| CHEMBL4756255 | — | — | 1 | 6.22 |
| CHEMBL4742688 | — | — | 1 | 5.80 |
| CHEMBL4762870 | — | — | 1 | 5.80 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL53463 | DOXORUBICIN | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL4764669 | — | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL4758181 | — | IC50 | = | 200.0 | nM | 6.70 |
| CHEMBL4800153 | — | IC50 | = | 500.0 | nM | 6.30 |
| CHEMBL4756255 | — | IC50 | = | 600.0 | nM | 6.22 |
| CHEMBL4742688 | — | IC50 | = | 1600.0 | nM | 5.80 |
| CHEMBL4762870 | — | IC50 | = | 1600.0 | nM | 5.80 |