Assay Detail
Functional
CHEMBL4669261
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Cytotoxicity against human HL-60 cells assessed as reduction in cell viability after 48 hrs by MTT assay
2
Total Activities
2
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | HL-60 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Development of SKI-349, a dual-targeted inhibitor of sphingosine kinase and microtubule polymerization.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 2 | 7.00 | 7.66 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL552462 | — | — | 1 | 7.66 |
| CHEMBL1289102 | — | — | 1 | 6.33 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL552462 | — | IC50 | = | 22.0 | nM | 7.66 |
| CHEMBL1289102 | — | IC50 | = | 470.0 | nM | 6.33 |