Assay Detail
Binding
CHEMBL4669384
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Inhibition of Class 1 HDAC in VSV-G-pseudotyped HIV infected human 2C4 cell Jurkat model assessed as reactivation of HIV latency in presence of 0.1% NHS by fluorescent reporter gene assay
24
Total Activities
24
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | 2C4 |
| Confidence | 5 — Multiple protein complex / RNA |
| Curated By | Autocuration |
Publication
Development of a selective HDAC inhibitor aimed at reactivating the HIV latent reservoir.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 24 | 6.33 | 7.11 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4746782 | — | — | 1 | 7.11 |
| CHEMBL4759693 | — | — | 1 | 6.98 |
| CHEMBL4797893 | — | — | 1 | 6.97 |
| CHEMBL4742036 | — | — | 1 | 6.81 |
| CHEMBL4759472 | — | — | 1 | 6.79 |
| CHEMBL4748244 | — | — | 1 | 6.78 |
| CHEMBL4785376 | — | — | 1 | 6.71 |
| CHEMBL4788911 | — | — | 1 | 6.63 |
| CHEMBL4761973 | — | — | 1 | 6.61 |
| CHEMBL4760209 | — | — | 1 | 6.59 |
| CHEMBL4776685 | — | — | 1 | 6.53 |
| CHEMBL4765128 | — | — | 1 | 6.26 |
| CHEMBL4746267 | — | — | 1 | 6.25 |
| CHEMBL4739902 | — | — | 1 | 6.25 |
| CHEMBL4782188 | — | — | 1 | 6.24 |
| CHEMBL4781191 | — | — | 1 | 6.11 |
| CHEMBL4761318 | — | — | 1 | 5.94 |
| CHEMBL4797194 | — | — | 1 | 5.91 |
| CHEMBL4754763 | — | — | 1 | 5.81 |
| CHEMBL4756752 | — | — | 1 | 5.79 |
| CHEMBL4741084 | — | — | 1 | 5.76 |
| CHEMBL4796175 | — | — | 1 | 5.74 |
| CHEMBL4750027 | — | — | 1 | 5.67 |
| CHEMBL4793558 | — | — | 1 | 5.56 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4746782 | — | EC50 | = | 77.0 | nM | 7.11 |
| CHEMBL4759693 | — | EC50 | = | 105.0 | nM | 6.98 |
| CHEMBL4797893 | — | EC50 | = | 107.0 | nM | 6.97 |
| CHEMBL4742036 | — | EC50 | = | 154.0 | nM | 6.81 |
| CHEMBL4759472 | — | EC50 | = | 161.0 | nM | 6.79 |
| CHEMBL4748244 | — | EC50 | = | 166.0 | nM | 6.78 |
| CHEMBL4785376 | — | EC50 | = | 193.0 | nM | 6.71 |
| CHEMBL4788911 | — | EC50 | = | 233.0 | nM | 6.63 |
| CHEMBL4761973 | — | EC50 | = | 247.0 | nM | 6.61 |
| CHEMBL4760209 | — | EC50 | = | 254.0 | nM | 6.59 |
| CHEMBL4776685 | — | EC50 | = | 294.0 | nM | 6.53 |
| CHEMBL4765128 | — | EC50 | = | 548.0 | nM | 6.26 |
| CHEMBL4746267 | — | EC50 | = | 566.0 | nM | 6.25 |
| CHEMBL4739902 | — | EC50 | = | 558.0 | nM | 6.25 |
| CHEMBL4782188 | — | EC50 | = | 570.0 | nM | 6.24 |
| CHEMBL4781191 | — | EC50 | = | 775.0 | nM | 6.11 |
| CHEMBL4761318 | — | EC50 | = | 1142.0 | nM | 5.94 |
| CHEMBL4797194 | — | EC50 | = | 1233.0 | nM | 5.91 |
| CHEMBL4754763 | — | EC50 | = | 1564.0 | nM | 5.81 |
| CHEMBL4756752 | — | EC50 | = | 1605.0 | nM | 5.79 |
| CHEMBL4741084 | — | EC50 | = | 1731.0 | nM | 5.76 |
| CHEMBL4796175 | — | EC50 | = | 1834.0 | nM | 5.74 |
| CHEMBL4750027 | — | EC50 | = | 2112.0 | nM | 5.67 |
| CHEMBL4793558 | — | EC50 | = | 2729.0 | nM | 5.56 |