Compound Detail
CHEMBL4761318
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CCC(=O)CCCCCC(NC(=O)c1cncs1)c1[nH]c(-c2ccccc2)nc1C(=O)NCCN(C)C
Basic Information
| ChEMBL ID | CHEMBL4761318 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | DPINOTMBVJNBFU-UHFFFAOYSA-N |
5
Targets
6
Activities
2
Assay Types
0
PK Parameters
6
Publications
0
Known Names
Molecular Properties
524.7
MW (Da)
4.23
ALogP
7
HBA
3
HBD
120.1
PSA (Ų)
0.26
QED
1
Ro5 Violations
15
Rot. Bonds
Drug Information
| Molecule Type | Unknown |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 4 meas. best 8.35
EC50 2 meas. best 6.07
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Histone deacetylase 3 CHEMBL1829 | IC50 | 8.35 | 8.35 | 4.5 | 1 |
| Histone deacetylase 1 CHEMBL325 | IC50 | 7.87 | 7.87 | 13.5 | 1 |
| Histone deacetylase 2 CHEMBL1937 | IC50 | 7.28 | 7.28 | 53.1 | 1 |
| Class 1 histone deacetylase CHEMBL4523988 | EC50 | 6.07 | 6.005 | 853.0 | 2 |
| Histone deacetylase 8 CHEMBL3192 | IC50 | 5.27 | 5.27 | 5335.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Histone deacetylase 3 | IC50 | = | 4.5 | nM | 8.35 | Inhibition of HDAC3 (unknown origin) | 32738976 |
| Histone deacetylase 1 | IC50 | = | 13.5 | nM | 7.87 | Inhibition of HDAC1 (unknown origin) | 32738976 |
| Histone deacetylase 2 | IC50 | = | 53.1 | nM | 7.28 | Inhibition of HDAC2 (unknown origin) | 32738976 |
| Class 1 histone deacetylase | EC50 | = | 853.0 | nM | 6.07 | Inhibition of Class 1 HDAC in VSV-G-pseudotyped HIV infected human 2C4 cell Jurk... | 32738976 |
| Class 1 histone deacetylase | EC50 | = | 1142.0 | nM | 5.94 | Inhibition of Class 1 HDAC in VSV-G-pseudotyped HIV infected human 2C4 cell Jurk... | 32738976 |
| Histone deacetylase 8 | IC50 | = | 5335.0 | nM | 5.27 | Inhibition of HDAC8 (unknown origin) | 32738976 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 32738976 | 10.1016/j.bmcl.2020.127367 | Class 1 histone deacetylase | 2 |
| 32738976 | 10.1016/j.bmcl.2020.127367 | Histone deacetylase 8 | 1 |
| 32738976 | 10.1016/j.bmcl.2020.127367 | Histone deacetylase 6 | 1 |
| 32738976 | 10.1016/j.bmcl.2020.127367 | Histone deacetylase 2 | 1 |
| 32738976 | 10.1016/j.bmcl.2020.127367 | Histone deacetylase 3 | 1 |
| 32738976 | 10.1016/j.bmcl.2020.127367 | Histone deacetylase 1 | 1 |
Data from ChEMBL 36 via Core Engine