Skip to main content
Free research Free research Free assay review with research home and workspace preview
Quick search ChEMBL 36
Assay Detail

CHEMBL4669389

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Inhibition of HDAC1 (unknown origin)
24
Total Activities
24
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Homo sapiens
Confidence 9 — Direct single protein target
Curated By Autocuration

Target

Histone deacetylase 1 (CHEMBL325)
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

Development of a selective HDAC inhibitor aimed at reactivating the HIV latent reservoir.
Clausen DJ,Liu J,Yu W,Duffy JL,Chung CC,Myers RW,Klein DJ,Fells J,Holloway K,Wu J,Wu G,Howell BJ,Barnard RJO,Kozlowski J
Bioorg Med Chem Lett (2020) 30 : 127367 -127367
PubMed 32738976 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 24 8.19 9.70

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL4746782 1 9.70
CHEMBL4759693 1 9.52
CHEMBL4761973 1 9.40
CHEMBL4785376 1 9.40
CHEMBL4748244 1 9.22
CHEMBL4776685 1 8.72
CHEMBL4759472 1 8.55
CHEMBL4781191 1 8.46
CHEMBL4797893 1 8.43
CHEMBL4788911 1 8.42
CHEMBL4741084 1 8.21
CHEMBL4742036 1 8.14
CHEMBL4760209 1 7.97
CHEMBL4796175 1 7.91
CHEMBL4761318 1 7.87
CHEMBL4746267 1 7.77
CHEMBL4754763 1 7.59
CHEMBL4782188 1 7.56
CHEMBL4739902 1 7.45
CHEMBL4797194 1 7.45
CHEMBL4793558 1 7.36
CHEMBL4756752 1 7.32
CHEMBL4750027 1 7.23
CHEMBL4765128 1 7.01

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL4746782 IC50 = 0.2 nM 9.70
CHEMBL4759693 IC50 = 0.3 nM 9.52
CHEMBL4761973 IC50 = 0.4 nM 9.40
CHEMBL4785376 IC50 = 0.4 nM 9.40
CHEMBL4748244 IC50 = 0.6 nM 9.22
CHEMBL4776685 IC50 = 1.9 nM 8.72
CHEMBL4759472 IC50 = 2.8 nM 8.55
CHEMBL4781191 IC50 = 3.5 nM 8.46
CHEMBL4797893 IC50 = 3.7 nM 8.43
CHEMBL4788911 IC50 = 3.8 nM 8.42
CHEMBL4741084 IC50 = 6.2 nM 8.21
CHEMBL4742036 IC50 = 7.2 nM 8.14
CHEMBL4760209 IC50 = 10.6 nM 7.97
CHEMBL4796175 IC50 = 12.3 nM 7.91
CHEMBL4761318 IC50 = 13.5 nM 7.87
CHEMBL4746267 IC50 = 17.0 nM 7.77
CHEMBL4754763 IC50 = 25.9 nM 7.59
CHEMBL4782188 IC50 = 27.6 nM 7.56
CHEMBL4739902 IC50 = 35.6 nM 7.45
CHEMBL4797194 IC50 = 35.2 nM 7.45
CHEMBL4793558 IC50 = 43.6 nM 7.36
CHEMBL4756752 IC50 = 47.9 nM 7.32
CHEMBL4750027 IC50 = 58.9 nM 7.23
CHEMBL4765128 IC50 = 97.9 nM 7.01