Assay Detail
Binding
CHEMBL4670082
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of PD1-Tag2/PD-L1-Tag1 (unknown origin) protein-protein interaction preincubated for 15 mins followed by addition of anti-Tag1-Eu3+ and anti-Tag2-XL665 measured after 3 hrs by HTRF assay
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 7 — Homologous single protein target |
| Curated By | Autocuration |
Target
Programmed cell death protein 1/Programmed cell death 1 ligand 1 (CHEMBL4523993) ↗| Type | PROTEIN COMPLEX |
| Organism | Homo sapiens |
Publication
Design and Discovery of Natural Cyclopeptide Skeleton Based Programmed Death Ligand 1 Inhibitor as Immune Modulator for Cancer Therapy.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 9 | 5.36 | 6.84 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4099869 | — | — | 1 | 6.84 |
| CHEMBL4793446 | — | — | 1 | 5.85 |
| CHEMBL4763429 | — | — | 1 | 5.30 |
| CHEMBL4781005 | — | — | 1 | 5.27 |
| CHEMBL4740780 | — | — | 1 | 5.20 |
| CHEMBL4793239 | — | — | 1 | 5.13 |
| CHEMBL4782871 | — | — | 1 | 5.09 |
| CHEMBL4789566 | — | — | 1 | 5.02 |
| CHEMBL4776498 | — | — | 1 | 4.56 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4099869 | — | IC50 | = | 146.0 | nM | 6.84 |
| CHEMBL4793446 | — | IC50 | = | 1420.0 | nM | 5.85 |
| CHEMBL4763429 | — | IC50 | = | 5020.0 | nM | 5.30 |
| CHEMBL4781005 | — | IC50 | = | 5370.0 | nM | 5.27 |
| CHEMBL4740780 | — | IC50 | = | 6350.0 | nM | 5.20 |
| CHEMBL4793239 | — | IC50 | = | 7420.0 | nM | 5.13 |
| CHEMBL4782871 | — | IC50 | = | 8100.0 | nM | 5.09 |
| CHEMBL4789566 | — | IC50 | = | 9630.0 | nM | 5.02 |
| CHEMBL4776498 | — | IC50 | = | 27500.0 | nM | 4.56 |