Assay Detail
Binding
CHEMBL4670126
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Antagonist activity at 5HT2B receptor (unknown origin) by radioligand binding assay
10
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Structure activity relationship exploration of 5-hydroxy-2-(3-phenylpropyl)chromones as a unique 5-HT receptor antagonist scaffold.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 10 | 5.90 | 7.10 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4796102 | — | — | 1 | 7.10 |
| CHEMBL4780527 | — | — | 1 | 6.00 |
| CHEMBL4795598 | — | — | 1 | 6.00 |
| CHEMBL4755344 | — | — | 1 | 5.90 |
| CHEMBL4741776 | — | — | 1 | 5.80 |
| CHEMBL4763861 | — | — | 1 | 5.70 |
| CHEMBL4790230 | — | — | 1 | 5.70 |
| CHEMBL4783824 | — | — | 1 | 5.60 |
| CHEMBL4743625 | — | — | 1 | 5.60 |
| CHEMBL4746138 | — | — | 1 | 5.60 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4796102 | — | Ki | = | 79.43 | nM | 7.10 |
| CHEMBL4780527 | — | Ki | = | 1000.0 | nM | 6.00 |
| CHEMBL4795598 | — | Ki | = | 1000.0 | nM | 6.00 |
| CHEMBL4755344 | — | Ki | = | 1258.93 | nM | 5.90 |
| CHEMBL4741776 | — | Ki | = | 1584.89 | nM | 5.80 |
| CHEMBL4763861 | — | Ki | = | 1995.26 | nM | 5.70 |
| CHEMBL4790230 | — | Ki | = | 1995.26 | nM | 5.70 |
| CHEMBL4783824 | — | Ki | = | 2511.89 | nM | 5.60 |
| CHEMBL4743625 | — | Ki | = | 2511.89 | nM | 5.60 |
| CHEMBL4746138 | — | Ki | = | 2511.89 | nM | 5.60 |