Assay Detail
ADMET
CHEMBL4670198
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Inhibition of CYP1A2 in human liver microsomes using phenacetin as substrate incubated for 5 to 20 mins in presence of NADPH by LC-MS/MS analysis
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | ADMET |
| Organism | Homo sapiens |
| Tissue | Liver |
| Subcellular | Microsomes |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Discovery of Potent and Selective PI3Kγ Inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 5.12 | 5.12 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4782083 | — | — | 1 | 5.12 |
| CHEMBL4755842 | — | — | 1 | - |
| CHEMBL4785086 | — | — | 1 | - |
| CHEMBL4742062 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4782083 | — | IC50 | = | 7500.0 | nM | 5.12 |
| CHEMBL4755842 | — | IC50 | > | 40000.0 | nM | - |
| CHEMBL4785086 | — | IC50 | > | 40000.0 | nM | - |
| CHEMBL4742062 | — | IC50 | - | — | - |