Assay Detail
ADMET
CHEMBL4670398
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Displacement of [3H]prazosin from alpha1 adrenergic receptor in rat cortex membranes measured after 30 mins by Microbeta2 scintillation counting method
34
Total Activities
34
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | ADMET |
| Organism | Rattus norvegicus |
| Tissue | Cortex |
| Confidence | 5 — Multiple protein complex / RNA |
| Curated By | Autocuration |
Publication
Discovery of Novel pERK1/2- or β-Arrestin-Preferring 5-HT Receptor-Biased Agonists: Diversified Therapeutic-like versus Side Effect Profile.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 32 | 6.75 | 7.76 |
| pKi | 2 | - | - |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4790600 | — | — | 1 | 7.76 |
| CHEMBL4800575 | — | — | 1 | 7.34 |
| CHEMBL4751777 | — | — | 1 | 7.18 |
| CHEMBL4756233 | — | — | 1 | 7.00 |
| CHEMBL4756041 | — | — | 1 | 6.76 |
| CHEMBL4744067 | — | — | 1 | 6.72 |
| CHEMBL4756322 | — | — | 1 | 6.71 |
| CHEMBL4743868 | — | — | 1 | 6.69 |
| CHEMBL4757755 | — | — | 1 | 6.36 |
| CHEMBL4741857 | — | — | 1 | 6.29 |
| CHEMBL4752833 | — | — | 1 | 6.20 |
| CHEMBL4781985 | — | — | 1 | 6.04 |
| CHEMBL4797282 | — | — | 1 | - |
| CHEMBL4759759 | — | — | 1 | - |
| CHEMBL4797752 | — | — | 1 | - |
| CHEMBL4786067 | — | — | 1 | - |
| CHEMBL4790662 | — | — | 1 | - |
| CHEMBL4747083 | — | — | 1 | - |
| CHEMBL4753394 | — | — | 1 | - |
| CHEMBL230963 | — | — | 1 | - |
| CHEMBL56 | 8-OH-DPAT | — | 1 | - |
| CHEMBL4750444 | — | — | 1 | - |
| CHEMBL4777581 | — | — | 1 | - |
| CHEMBL4796345 | — | — | 1 | - |
| CHEMBL4760666 | — | — | 1 | - |
| CHEMBL4755058 | — | — | 1 | - |
| CHEMBL4752177 | — | — | 1 | - |
| CHEMBL4760621 | — | — | 1 | - |
| CHEMBL4740430 | — | — | 1 | - |
| CHEMBL49 | BUSPIRONE | 4.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4790600 | — | Ki | = | 17.38 | nM | 7.76 |
| CHEMBL4800575 | — | Ki | = | 45.71 | nM | 7.34 |
| CHEMBL4751777 | — | Ki | = | 66.07 | nM | 7.18 |
| CHEMBL4756233 | — | Ki | = | 100.0 | nM | 7.00 |
| CHEMBL4756041 | — | Ki | = | 173.78 | nM | 6.76 |
| CHEMBL4744067 | — | Ki | = | 190.55 | nM | 6.72 |
| CHEMBL4756322 | — | Ki | = | 194.98 | nM | 6.71 |
| CHEMBL4743868 | — | Ki | = | 204.17 | nM | 6.69 |
| CHEMBL4757755 | — | Ki | = | 436.52 | nM | 6.36 |
| CHEMBL4741857 | — | Ki | = | 512.86 | nM | 6.29 |
| CHEMBL4752833 | — | Ki | = | 630.96 | nM | 6.20 |
| CHEMBL4781985 | — | Ki | = | 912.01 | nM | 6.04 |
| CHEMBL4760271 | — | Ki | > | 1000.0 | nM | - |
| CHEMBL4739908 | — | Ki | > | 1000.0 | nM | - |
| CHEMBL4747425 | — | Ki | > | 1000.0 | nM | - |
| CHEMBL4746386 | — | Ki | > | 1000.0 | nM | - |
| CHEMBL4797282 | — | Ki | > | 1000.0 | nM | - |
| CHEMBL4759759 | — | Ki | > | 1000.0 | nM | - |
| CHEMBL4797752 | — | Ki | > | 1000.0 | nM | - |
| CHEMBL4786067 | — | Ki | > | 1000.0 | nM | - |
| CHEMBL4790662 | — | Ki | > | 1000.0 | nM | - |
| CHEMBL4747083 | — | Ki | > | 1000.0 | nM | - |
| CHEMBL4753394 | — | Ki | > | 1000.0 | nM | - |
| CHEMBL230963 | — | Ki | > | 1000.0 | nM | - |
| CHEMBL56 | 8-OH-DPAT | pKi | - | — | - | |
| CHEMBL4750444 | — | Ki | > | 1000.0 | nM | - |
| CHEMBL4777581 | — | Ki | > | 1000.0 | nM | - |
| CHEMBL4796345 | — | Ki | > | 1000.0 | nM | - |
| CHEMBL4760666 | — | Ki | > | 1000.0 | nM | - |
| CHEMBL4755058 | — | Ki | > | 1000.0 | nM | - |
| CHEMBL4752177 | — | Ki | > | 1000.0 | nM | - |
| CHEMBL4760621 | — | Ki | > | 1000.0 | nM | - |
| CHEMBL4740430 | — | Ki | > | 1000.0 | nM | - |
| CHEMBL49 | BUSPIRONE | pKi | - | — | - |