Assay Detail
Functional
CHEMBL4670405
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Biased agonist activity at human 5-HT1A receptor stably expressed in CHO-K1 cells assessed as inhibition of forskolin-induced cAMP accumulation after 40 mins by LANCE Ultra cAMP kit-based TR-FRET assay
30
Total Activities
30
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | CHO-K1 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Discovery of Novel pERK1/2- or β-Arrestin-Preferring 5-HT Receptor-Biased Agonists: Diversified Therapeutic-like versus Side Effect Profile.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 30 | 8.19 | 10.88 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4757755 | — | — | 1 | 10.88 |
| CHEMBL4755058 | — | — | 1 | 10.86 |
| CHEMBL4752177 | — | — | 1 | 10.18 |
| CHEMBL4756233 | — | — | 1 | 10.06 |
| CHEMBL4796345 | — | — | 1 | 9.95 |
| CHEMBL4751777 | — | — | 1 | 9.86 |
| CHEMBL4756041 | — | — | 1 | 9.47 |
| CHEMBL4777581 | — | — | 1 | 9.18 |
| CHEMBL4786067 | — | — | 1 | 8.98 |
| CHEMBL4750444 | — | — | 1 | 8.22 |
| CHEMBL4790600 | — | — | 1 | 8.18 |
| CHEMBL4741857 | — | — | 1 | 8.09 |
| CHEMBL4760621 | — | — | 1 | 7.83 |
| CHEMBL4781985 | — | — | 1 | 7.82 |
| CHEMBL4739908 | — | — | 1 | 7.80 |
| CHEMBL4760666 | — | — | 1 | 7.77 |
| CHEMBL4760271 | — | — | 1 | 7.74 |
| CHEMBL4797282 | — | — | 1 | 7.71 |
| CHEMBL4790662 | — | — | 1 | 7.69 |
| CHEMBL4746386 | — | — | 1 | 7.59 |
| CHEMBL39 | SEROTONIN | 3.0 | 1 | 7.51 |
| CHEMBL56 | 8-OH-DPAT | — | 1 | 7.50 |
| CHEMBL4752833 | — | — | 1 | 7.40 |
| CHEMBL4747425 | — | — | 1 | 7.37 |
| CHEMBL230963 | — | — | 1 | 7.22 |
| CHEMBL49 | BUSPIRONE | 4.0 | 1 | 7.14 |
| CHEMBL4740430 | — | — | 1 | 6.56 |
| CHEMBL4753394 | — | — | 1 | 6.48 |
| CHEMBL4797752 | — | — | 1 | 6.32 |
| CHEMBL4747083 | — | — | 1 | 6.25 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4757755 | — | EC50 | = | 0.01318 | nM | 10.88 |
| CHEMBL4755058 | — | EC50 | = | 0.0138 | nM | 10.86 |
| CHEMBL4752177 | — | EC50 | = | 0.06607 | nM | 10.18 |
| CHEMBL4756233 | — | EC50 | = | 0.0871 | nM | 10.06 |
| CHEMBL4796345 | — | EC50 | = | 0.1122 | nM | 9.95 |
| CHEMBL4751777 | — | EC50 | = | 0.138 | nM | 9.86 |
| CHEMBL4756041 | — | EC50 | = | 0.3388 | nM | 9.47 |
| CHEMBL4777581 | — | EC50 | = | 0.6607 | nM | 9.18 |
| CHEMBL4786067 | — | EC50 | = | 1.047 | nM | 8.98 |
| CHEMBL4750444 | — | EC50 | = | 6.026 | nM | 8.22 |
| CHEMBL4790600 | — | EC50 | = | 6.607 | nM | 8.18 |
| CHEMBL4741857 | — | EC50 | = | 8.128 | nM | 8.09 |
| CHEMBL4760621 | — | EC50 | = | 14.79 | nM | 7.83 |
| CHEMBL4781985 | — | EC50 | = | 15.14 | nM | 7.82 |
| CHEMBL4739908 | — | EC50 | = | 15.85 | nM | 7.80 |
| CHEMBL4760666 | — | EC50 | = | 16.98 | nM | 7.77 |
| CHEMBL4760271 | — | EC50 | = | 18.2 | nM | 7.74 |
| CHEMBL4797282 | — | EC50 | = | 19.5 | nM | 7.71 |
| CHEMBL4790662 | — | EC50 | = | 20.42 | nM | 7.69 |
| CHEMBL4746386 | — | EC50 | = | 25.7 | nM | 7.59 |
| CHEMBL39 | SEROTONIN | EC50 | = | 30.9 | nM | 7.51 |
| CHEMBL56 | 8-OH-DPAT | EC50 | = | 31.62 | nM | 7.50 |
| CHEMBL4752833 | — | EC50 | = | 39.81 | nM | 7.40 |
| CHEMBL4747425 | — | EC50 | = | 42.66 | nM | 7.37 |
| CHEMBL230963 | — | EC50 | = | 60.26 | nM | 7.22 |
| CHEMBL49 | BUSPIRONE | EC50 | = | 72.44 | nM | 7.14 |
| CHEMBL4740430 | — | EC50 | = | 275.42 | nM | 6.56 |
| CHEMBL4753394 | — | EC50 | = | 331.13 | nM | 6.48 |
| CHEMBL4797752 | — | EC50 | = | 478.63 | nM | 6.32 |
| CHEMBL4747083 | — | EC50 | = | 562.34 | nM | 6.25 |