Assay Detail
Binding
CHEMBL4670525
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antagonist activity at ER-alpha in human MCF-7:WS8 cells transfected with an estrogen response element assessed as suppression of estrogen-induced response incubated for 18 hrs by luciferase reporter gene assay
4
Total Activities
4
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | MCF7 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Screening and Reverse-Engineering of Estrogen Receptor Ligands as Potent Pan-Filovirus Inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 2 | 8.73 | 9.22 |
| Inhibition | 2 | - | - |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL392916 | — | — | 1 | 9.22 |
| CHEMBL81 | RALOXIFENE | 4.0 | 1 | 8.23 |
| CHEMBL4754810 | — | — | 1 | - |
| CHEMBL4782391 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL392916 | — | IC50 | = | 0.6 | nM | 9.22 |
| CHEMBL81 | RALOXIFENE | IC50 | = | 5.9 | nM | 8.23 |
| CHEMBL4754810 | — | Inhibition | - | % | - | |
| CHEMBL4782391 | — | Inhibition | - | % | - |