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Assay Detail

CHEMBL4670537

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
Antiviral activity against pseudotyped Marburgvirus-Angola infected in human A549 cells assessed as reduction in viral infection incubated for 24 hrs by Hoechst staining based fluorescence assay
18
Total Activities
18
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Marburgvirus
Cell Type A549
Confidence 1 — Organism
Curated By Autocuration

Target

Marburgvirus (CHEMBL4296577)
Type ORGANISM
Organism Marburgvirus

Publication

Screening and Reverse-Engineering of Estrogen Receptor Ligands as Potent Pan-Filovirus Inhibitors.
Cooper L,Schafer A,Li Y,Cheng H,Medegan Fagla B,Shen Z,Nowar R,Dye K,Anantpadma M,Davey RA,Thatcher GRJ,Rong L,Xiong R
J Med Chem (2020) 63 : 11085 -11099
PubMed 32886512 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 18 5.85 6.44

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL4761341 1 6.44
CHEMBL4754810 1 6.19
CHEMBL4751531 1 6.06
CHEMBL4782391 1 6.02
CHEMBL4796723 1 5.97
CHEMBL4757636 1 5.97
CHEMBL392916 1 5.81
CHEMBL4745844 1 5.75
CHEMBL4742939 1 5.55
CHEMBL4795040 1 5.54
CHEMBL4760524 1 5.49
CHEMBL1655 TOREMIFENE 4.0 1 5.41
CHEMBL4743737 1 -
CHEMBL4532671 1 -
CHEMBL226327 1 -
CHEMBL226329 1 -
CHEMBL4741938 1 -
CHEMBL28211 NAFOXIDINE 2.0 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL4761341 IC50 = 360.0 nM 6.44
CHEMBL4754810 IC50 = 640.0 nM 6.19
CHEMBL4751531 IC50 = 870.0 nM 6.06
CHEMBL4782391 IC50 = 960.0 nM 6.02
CHEMBL4796723 IC50 = 1070.0 nM 5.97
CHEMBL4757636 IC50 = 1060.0 nM 5.97
CHEMBL392916 IC50 = 1560.0 nM 5.81
CHEMBL4745844 IC50 = 1780.0 nM 5.75
CHEMBL4742939 IC50 = 2800.0 nM 5.55
CHEMBL4795040 IC50 = 2900.0 nM 5.54
CHEMBL4760524 IC50 = 3240.0 nM 5.49
CHEMBL1655 TOREMIFENE IC50 = 3900.0 nM 5.41
CHEMBL4743737 IC50 > 25000.0 nM -
CHEMBL4532671 IC50 > 6250.0 nM -
CHEMBL226327 IC50 > 6250.0 nM -
CHEMBL226329 IC50 > 6250.0 nM -
CHEMBL4741938 IC50 > 6250.0 nM -
CHEMBL28211 NAFOXIDINE IC50 > 6250.0 nM -