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Assay Detail

CHEMBL4670543

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
Antiviral activity against pseudotyped Marburgvirus-Musoke infected in human A549 cells assessed as reduction in viral infection incubated for 48 hrs by luciferase reporter gene assay
31
Total Activities
31
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Marburgvirus
Cell Type A549
Confidence 1 — Organism
Curated By Autocuration

Target

Marburgvirus (CHEMBL4296577)
Type ORGANISM
Organism Marburgvirus

Publication

Screening and Reverse-Engineering of Estrogen Receptor Ligands as Potent Pan-Filovirus Inhibitors.
Cooper L,Schafer A,Li Y,Cheng H,Medegan Fagla B,Shen Z,Nowar R,Dye K,Anantpadma M,Davey RA,Thatcher GRJ,Rong L,Xiong R
J Med Chem (2020) 63 : 11085 -11099
PubMed 32886512 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 31 5.80 6.38

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL4761341 1 6.38
CHEMBL4754810 1 6.27
CHEMBL4797649 1 6.22
CHEMBL4751531 1 6.21
CHEMBL392916 1 6.21
CHEMBL226327 1 6.17
CHEMBL4782391 1 6.14
CHEMBL4757636 1 6.12
CHEMBL4747864 1 6.05
CHEMBL4745844 1 5.97
CHEMBL4742939 1 5.92
CHEMBL520107 1 5.92
CHEMBL4746824 1 5.90
CHEMBL28211 NAFOXIDINE 2.0 1 5.89
CHEMBL4297509 ELACESTRANT 4.0 1 5.89
CHEMBL226329 1 5.84
CHEMBL83 TAMOXIFEN 4.0 1 5.74
CHEMBL4751659 1 5.74
CHEMBL4543096 1 5.73
CHEMBL226269 1 5.69
CHEMBL4796723 1 5.69
CHEMBL4795040 1 5.66
CHEMBL81 RALOXIFENE 4.0 1 5.66
CHEMBL1655 TOREMIFENE 4.0 1 5.58
CHEMBL4741938 1 5.50
CHEMBL46740 BAZEDOXIFENE 4.0 1 5.42
CHEMBL4532671 1 5.41
CHEMBL4760524 1 5.37
CHEMBL4754864 1 5.36
CHEMBL2105395 OSPEMIFENE 4.0 1 4.46

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL4761341 IC50 = 420.0 nM 6.38
CHEMBL4754810 IC50 = 540.0 nM 6.27
CHEMBL4797649 IC50 = 600.0 nM 6.22
CHEMBL4751531 IC50 = 620.0 nM 6.21
CHEMBL392916 IC50 = 610.0 nM 6.21
CHEMBL226327 IC50 = 670.0 nM 6.17
CHEMBL4782391 IC50 = 720.0 nM 6.14
CHEMBL4757636 IC50 = 750.0 nM 6.12
CHEMBL4747864 IC50 = 900.0 nM 6.05
CHEMBL4745844 IC50 = 1070.0 nM 5.97
CHEMBL4742939 IC50 = 1210.0 nM 5.92
CHEMBL520107 IC50 = 1190.0 nM 5.92
CHEMBL4746824 IC50 = 1250.0 nM 5.90
CHEMBL28211 NAFOXIDINE IC50 = 1300.0 nM 5.89
CHEMBL4297509 ELACESTRANT IC50 = 1300.0 nM 5.89
CHEMBL226329 IC50 = 1450.0 nM 5.84
CHEMBL83 TAMOXIFEN IC50 = 1810.0 nM 5.74
CHEMBL4751659 IC50 = 1810.0 nM 5.74
CHEMBL4543096 IC50 = 1870.0 nM 5.73
CHEMBL226269 IC50 = 2040.0 nM 5.69
CHEMBL4796723 IC50 = 2050.0 nM 5.69
CHEMBL4795040 IC50 = 2180.0 nM 5.66
CHEMBL81 RALOXIFENE IC50 = 2200.0 nM 5.66
CHEMBL1655 TOREMIFENE IC50 = 2600.0 nM 5.58
CHEMBL4741938 IC50 = 3180.0 nM 5.50
CHEMBL46740 BAZEDOXIFENE IC50 = 3830.0 nM 5.42
CHEMBL4532671 IC50 = 3880.0 nM 5.41
CHEMBL4760524 IC50 = 4230.0 nM 5.37
CHEMBL4754864 IC50 = 4400.0 nM 5.36
CHEMBL2105395 OSPEMIFENE IC50 = 34350.0 nM 4.46
CHEMBL4743737 IC50 > 12500.0 nM -