Assay Detail
Binding
CHEMBL4670677
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Agonist activity at DOP (unknown origin) expressed in SH-SY5Y cell membranes co-expressing Gbeta1-RGFP protein assessed as induction of G protein activation incubated for 15 mins by BRET assay
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | SH-SY5Y |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Biased Agonism at Nociceptin/Orphanin FQ Receptors: A Structure Activity Study on N/OFQ(1-13)-NH.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 5 | 7.70 | 8.69 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4749747 | — | — | 1 | 8.69 |
| CHEMBL4747671 | — | — | 1 | 8.09 |
| CHEMBL273820 | — | — | 1 | 7.58 |
| CHEMBL4789975 | — | — | 1 | 7.23 |
| CHEMBL8234 | ENKEPHALIN | — | 1 | 6.92 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4749747 | — | EC50 | = | 2.042 | nM | 8.69 |
| CHEMBL4747671 | — | EC50 | = | 8.128 | nM | 8.09 |
| CHEMBL273820 | — | EC50 | = | 26.3 | nM | 7.58 |
| CHEMBL4789975 | — | EC50 | = | 58.88 | nM | 7.23 |
| CHEMBL8234 | ENKEPHALIN | EC50 | = | 120.23 | nM | 6.92 |