Compound Detail
CHEMBL8234
ENKEPHALIN Enter ChEMBL ID:
Free Research Context
This compound will appear in recent viewed items on the research home for this browser.
Research home
View demo workspace
CC(C)C[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)CNC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)O
Basic Information
| ChEMBL ID | CHEMBL8234 |
| Name | ENKEPHALIN |
| Phase | Preclinical |
| Structure Type | BOTH |
| InChI Key | URLZCHNOLZSCCA-VABKMULXSA-N |
19
Targets
111
Activities
4
Assay Types
14
PK Parameters
20
Publications
0
Known Names
Molecular Properties
555.6
MW (Da)
-0.16
ALogP
7
HBA
7
HBD
199.9
PSA (Ų)
0.16
QED
2
Ro5 Violations
15
Rot. Bonds
Drug Information
| Molecule Type | Protein |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
Ki 52 meas. best 9.15
IC50 40 meas. best 8.97
EC50 18 meas. best 10.1
Kd 1 meas. best 8.15
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Delta-type opioid receptor CHEMBL236 | EC50 | 10.1 | 8.4213 | 0.1 | 8 |
| Delta-type opioid receptor CHEMBL236 | Ki | 9.15 | 8.5564 | 0.7 | 11 |
| Delta-type opioid receptor CHEMBL3222 | IC50 | 8.97 | 8.3444 | 1.1 | 9 |
| Mu-type opioid receptor CHEMBL233 | EC50 | 8.89 | 7.0683 | 1.3 | 6 |
| Delta-type opioid receptor CHEMBL269 | Ki | 8.85 | 8.5223 | 1.4 | 13 |
| Mu-type opioid receptor CHEMBL233 | Ki | 8.69 | 7.596 | 2.0 | 5 |
| Mu-type opioid receptor CHEMBL270 | Ki | 8.62 | 8.0533 | 2.4 | 12 |
| Delta-type opioid receptor CHEMBL3222 | Ki | 8.2 | 8.18 | 6.3 | 2 |
| Proenkephalin-B CHEMBL2227 | Kd | 8.15 | 8.15 | 7.1 | 1 |
| Opioid receptor CHEMBL2095192 | IC50 | 8.08 | 7.6 | 8.4 | 2 |
| Mus musculus CHEMBL375 | IC50 | 8.07 | 7.9586 | 8.6 | 7 |
| Mu-type opioid receptor CHEMBL4354 | Ki | 8.03 | 7.225 | 9.4 | 2 |
| Mu-type opioid receptor CHEMBL2858 | IC50 | 8.03 | 7.81 | 9.4 | 3 |
| Rattus norvegicus CHEMBL376 | IC50 | 7.96 | 7.96 | 11.0 | 1 |
| Monoclonal antibody (mAb) 3E7 CHEMBL613295 | IC50 | 7.76 | 7.76 | 17.5 | 1 |
| Delta-type opioid receptor CHEMBL269 | IC50 | 7.75 | 7.75 | 17.7 | 1 |
| Mu-type opioid receptor CHEMBL270 | IC50 | 7.3 | 7.3 | 49.8 | 1 |
| Unchecked CHEMBL612545 | Ki | 7.19 | 6.61 | 64.7 | 3 |
| Opioid receptor homologue CHEMBL4105897 | Ki | 7.14 | 7.14 | 73.0 | 1 |
| Delta-type opioid receptor CHEMBL3222 | EC50 | 7.13 | 7.13 | 74.0 | 1 |
| Kappa-type opioid receptor CHEMBL237 | EC50 | 7.1 | 7.1 | 80.0 | 3 |
| Unchecked CHEMBL612545 | IC50 | 7.0 | 7.0 | 100.0 | 1 |
| Mu-type opioid receptor CHEMBL4354 | IC50 | 6.99 | 6.6733 | 103.0 | 6 |
| Opioid receptor, delta 1b CHEMBL4105711 | Ki | 6.76 | 6.76 | 175.0 | 1 |
| Cavia porcellus CHEMBL369 | IC50 | 6.67 | 6.6186 | 213.0 | 7 |
| Mu opioid receptor-like OR2 CHEMBL3611961 | Ki | 5.88 | 5.88 | 1317.0 | 1 |
| Kappa-type opioid receptor CHEMBL3952 | Ki | 5.34 | 5.34 | 4570.0 | 1 |
| Mu-type opioid receptor CHEMBL233 | IC50 | 5.02 | 5.02 | 9500.0 | 1 |
Pharmacokinetic Data
| Parameter | Value | Units | Species |
|---|---|---|---|
| Ke | 1.53 | nM | Cavia porcellus |
| Ke | 5.86 | nM | Mus musculus |
| Ke | 1.53 | nM | Cavia porcellus |
| Ke | 1.53 | nM | Cavia porcellus |
| Ke | 1.53 | nM | Cavia porcellus |
| Ke | 21.4 | nM | Mus musculus |
| T1/2 | 13.5 | hr | Homo sapiens |
| T1/2 | 0.0115 | hr | Homo sapiens |
| T1/2 | 2.167 | hr | Homo sapiens |
| T1/2 | 0.08333 | hr | Rattus norvegicus |
| T1/2 | 0.07667 | hr | Rattus norvegicus |
| T1/2 | 0.08333 | hr | Rattus norvegicus |
| T1/2 | 0.2 | hr | Homo sapiens |
| T1/2 | 0.0115 | hr | Homo sapiens |
Activity Data Samples
Top measurements by pChEMBL value
Literature References
Data from ChEMBL 36 via Core Engine