Assay Detail
Functional
CHEMBL4732999
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Agonist activity at human mu opioid receptor expressed in CHO-K1 cells assessed as inhibition of forskolin-induced cAMP accumulation incubated for 30 mins by luminescence-based assay
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | CHO-K1 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Amide Bond Bioisosteres: Strategies, Synthesis, and Successes.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 4 | 8.06 | 8.89 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL8234 | ENKEPHALIN | — | 1 | 8.89 |
| CHEMBL4531563 | — | — | 1 | 7.22 |
| CHEMBL4754251 | — | — | 1 | - |
| CHEMBL4749699 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL8234 | ENKEPHALIN | EC50 | = | 1.3 | nM | 8.89 |
| CHEMBL4531563 | — | EC50 | = | 60.0 | nM | 7.22 |
| CHEMBL4754251 | — | EC50 | > | 10000.0 | nM | - |
| CHEMBL4749699 | — | EC50 | > | 10000.0 | nM | - |