Assay Detail
Functional
CHEMBL4814802
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Agonist activity at mouse FLAG-tagged delta opioid receptor expressed in HEK293 cells assessed as inhibition of forskolin-induced cAMP production preincubated for 20 mins followed by forskolin stimulation and measured after 15 mins by Glo-sensor reagent based assay
11
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Mus musculus |
| Cell Type | HEK293 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Isolation and Pharmacological Characterization of Six Opioidergic <i>Picralima nitida</i> Alkaloids.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 11 | 5.44 | 8.90 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL8234 | ENKEPHALIN | — | 2 | 8.90 |
| CHEMBL508955 | AKUAMMICINE | — | 2 | 4.91 |
| CHEMBL4856018 | — | — | 2 | 4.81 |
| CHEMBL4871880 | — | — | 2 | 4.70 |
| CHEMBL4874877 | — | — | 2 | 4.61 |
| CHEMBL4846243 | — | — | 1 | 4.02 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL8234 | ENKEPHALIN | IC50 | = | 1.259 | nM | 8.90 |
| CHEMBL8234 | ENKEPHALIN | IC50 | = | 1.4 | nM | 8.85 |
| CHEMBL508955 | AKUAMMICINE | IC50 | = | 12400.0 | nM | 4.91 |
| CHEMBL508955 | AKUAMMICINE | IC50 | = | 12589.25 | nM | 4.90 |
| CHEMBL4856018 | — | IC50 | = | 15400.0 | nM | 4.81 |
| CHEMBL4856018 | — | IC50 | = | 15848.93 | nM | 4.80 |
| CHEMBL4871880 | — | IC50 | = | 19952.62 | nM | 4.70 |
| CHEMBL4871880 | — | IC50 | = | 20300.0 | nM | 4.69 |
| CHEMBL4874877 | — | IC50 | = | 24400.0 | nM | 4.61 |
| CHEMBL4874877 | — | IC50 | = | 25118.86 | nM | 4.60 |
| CHEMBL4846243 | — | IC50 | = | 95600.0 | nM | 4.02 |