Assay Detail
Binding
CHEMBL4670679
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Agonist activity at DOP (unknown origin) expressed in SH-SY5Y cell membranes co-expressing beta-arrestin2-RGFP protein assessed as induction of beta-arrestin2 activation incubated for 15 mins by BRET assay
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | SH-SY5Y |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Biased Agonism at Nociceptin/Orphanin FQ Receptors: A Structure Activity Study on N/OFQ(1-13)-NH.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 5 | 7.19 | 7.83 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL273820 | — | — | 1 | 7.83 |
| CHEMBL4749747 | — | — | 1 | 7.65 |
| CHEMBL8234 | ENKEPHALIN | — | 1 | 7.37 |
| CHEMBL4747671 | — | — | 1 | 6.88 |
| CHEMBL4789975 | — | — | 1 | 6.21 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL273820 | — | EC50 | = | 14.79 | nM | 7.83 |
| CHEMBL4749747 | — | EC50 | = | 22.39 | nM | 7.65 |
| CHEMBL8234 | ENKEPHALIN | EC50 | = | 42.66 | nM | 7.37 |
| CHEMBL4747671 | — | EC50 | = | 131.83 | nM | 6.88 |
| CHEMBL4789975 | — | EC50 | = | 616.6 | nM | 6.21 |