Assay Detail
Binding
CHEMBL4670815
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of FITC-labeled palmitate tracer binding to N-terminal His6-tagged human TEAD4 (217 to 434 residues) expressed in Escherichia coli BL21-CodonPlus (DE3)-RIPL cells preincubated for 10 mins followed by FITC-labeled palmitate tracer addition and measured after 1 hr by fluorescence assay
31
Total Activities
31
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Transcriptional enhancer factor TEF-3 (CHEMBL4295828) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Discovery of Covalent Inhibitors Targeting the Transcriptional Enhanced Associate Domain Central Pocket.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 31 | 5.82 | 7.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4787565 | — | — | 1 | 7.00 |
| CHEMBL4757369 | — | — | 1 | 6.70 |
| CHEMBL242708 | — | — | 1 | 6.70 |
| CHEMBL4745831 | — | — | 1 | 6.70 |
| CHEMBL4745853 | — | — | 1 | 6.70 |
| CHEMBL4757924 | — | — | 1 | 6.70 |
| CHEMBL4776143 | — | — | 1 | 6.70 |
| CHEMBL1701986 | — | — | 1 | 6.52 |
| CHEMBL4789889 | — | — | 1 | 6.52 |
| CHEMBL4797833 | — | — | 1 | 6.52 |
| CHEMBL4744235 | — | — | 1 | 6.52 |
| CHEMBL4783341 | — | — | 1 | 6.52 |
| CHEMBL4750726 | — | — | 1 | 6.52 |
| CHEMBL4800702 | — | — | 1 | 6.40 |
| CHEMBL4750624 | — | — | 1 | 6.40 |
| CHEMBL4757939 | — | — | 1 | 6.30 |
| CHEMBL4784286 | — | — | 1 | 6.05 |
| CHEMBL4797545 | — | — | 1 | 5.96 |
| CHEMBL4778316 | — | — | 1 | 5.82 |
| CHEMBL4751604 | — | — | 1 | 5.25 |
| CHEMBL63323 | NIFLUMIC ACID | 2.0 | 1 | 5.23 |
| CHEMBL4781890 | — | — | 1 | 5.19 |
| CHEMBL4759333 | — | — | 1 | 4.87 |
| CHEMBL4763473 | — | — | 1 | 4.85 |
| CHEMBL4747774 | — | — | 1 | 4.83 |
| CHEMBL4759934 | — | — | 1 | 4.80 |
| CHEMBL4764516 | — | — | 1 | 4.65 |
| CHEMBL4751406 | — | — | 1 | 4.44 |
| CHEMBL4760394 | — | — | 1 | 4.42 |
| CHEMBL4786804 | — | — | 1 | 4.38 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4787565 | — | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL4757369 | — | IC50 | = | 200.0 | nM | 6.70 |
| CHEMBL242708 | — | IC50 | = | 200.0 | nM | 6.70 |
| CHEMBL4745831 | — | IC50 | = | 200.0 | nM | 6.70 |
| CHEMBL4745853 | — | IC50 | = | 200.0 | nM | 6.70 |
| CHEMBL4757924 | — | IC50 | = | 200.0 | nM | 6.70 |
| CHEMBL4776143 | — | IC50 | = | 200.0 | nM | 6.70 |
| CHEMBL1701986 | — | IC50 | = | 300.0 | nM | 6.52 |
| CHEMBL4789889 | — | IC50 | = | 300.0 | nM | 6.52 |
| CHEMBL4797833 | — | IC50 | = | 300.0 | nM | 6.52 |
| CHEMBL4744235 | — | IC50 | = | 300.0 | nM | 6.52 |
| CHEMBL4783341 | — | IC50 | = | 300.0 | nM | 6.52 |
| CHEMBL4750726 | — | IC50 | = | 300.0 | nM | 6.52 |
| CHEMBL4800702 | — | IC50 | = | 400.0 | nM | 6.40 |
| CHEMBL4750624 | — | IC50 | = | 400.0 | nM | 6.40 |
| CHEMBL4757939 | — | IC50 | = | 500.0 | nM | 6.30 |
| CHEMBL4784286 | — | IC50 | = | 900.0 | nM | 6.05 |
| CHEMBL4797545 | — | IC50 | = | 1100.0 | nM | 5.96 |
| CHEMBL4778316 | — | IC50 | = | 1500.0 | nM | 5.82 |
| CHEMBL4751604 | — | IC50 | = | 5600.0 | nM | 5.25 |
| CHEMBL63323 | NIFLUMIC ACID | IC50 | = | 5900.0 | nM | 5.23 |
| CHEMBL4781890 | — | IC50 | = | 6400.0 | nM | 5.19 |
| CHEMBL4759333 | — | IC50 | = | 13400.0 | nM | 4.87 |
| CHEMBL4763473 | — | IC50 | = | 14100.0 | nM | 4.85 |
| CHEMBL4747774 | — | IC50 | = | 14700.0 | nM | 4.83 |
| CHEMBL4759934 | — | IC50 | = | 16000.0 | nM | 4.80 |
| CHEMBL4764516 | — | IC50 | = | 22600.0 | nM | 4.65 |
| CHEMBL4751406 | — | IC50 | = | 36400.0 | nM | 4.44 |
| CHEMBL4760394 | — | IC50 | = | 38100.0 | nM | 4.42 |
| CHEMBL4786804 | — | IC50 | = | 41600.0 | nM | 4.38 |
| CHEMBL4798108 | — | IC50 | = | 49900.0 | nM | 4.30 |