Compound Detail
CHEMBL4751604
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Basic Information
| ChEMBL ID | CHEMBL4751604 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | ORPGRBXPGODSFW-UHFFFAOYSA-N |
1
Targets
2
Activities
1
Assay Types
0
PK Parameters
1
Publications
0
Known Names
Molecular Properties
330.4
MW (Da)
2.50
ALogP
7
HBA
3
HBD
95.6
PSA (Ų)
0.67
QED
0
Ro5 Violations
5
Rot. Bonds
Drug Information
| Molecule Type | Unknown |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 2 meas. best 5.25
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Transcriptional enhancer factor TEF-3 CHEMBL4295828 | IC50 | 5.25 | 4.76 | 5600.0 | 2 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Transcriptional enhancer factor TEF-3 | IC50 | = | 5600.0 | nM | 5.25 | Inhibition of FITC-labeled palmitate tracer binding to N-terminal His6-tagged hu... | 32907324 |
| Transcriptional enhancer factor TEF-3 | IC50 | = | 53400.0 | nM | 4.27 | Inhibition of CPM binding to N-terminal His6-tagged human TEAD4 (217 to 434 resi... | 32907324 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 32907324 | 10.1021/acs.jmedchem.0c01275 | Transcriptional enhancer factor TEF-3 | 4 |
Data from ChEMBL 36 via Core Engine