Assay Detail
Binding
CHEMBL4670928
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibiton of EGFR (unknown origin) expressed in human A431 cells assessed as reduction in EGFR induced cell viability after 96 hrs by CellTiter-Glo assay
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | A-431 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Targeting Her2-insYVMA with Covalent Inhibitors-A Focused Compound Screening and Structure-Based Design Approach.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 8 | 5.72 | 6.06 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4757145 | — | — | 1 | 6.06 |
| CHEMBL3353410 | OSIMERTINIB | 4.0 | 1 | 6.04 |
| CHEMBL1173655 | AFATINIB | 4.0 | 1 | 5.85 |
| CHEMBL4795165 | — | — | 1 | 5.80 |
| CHEMBL4787483 | — | — | 1 | 5.78 |
| CHEMBL4756368 | — | — | 1 | 5.65 |
| CHEMBL554 | LAPATINIB | 4.0 | 1 | 5.57 |
| CHEMBL180022 | NERATINIB | 4.0 | 1 | 5.00 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4757145 | — | IC50 | = | 862.0 | nM | 6.06 |
| CHEMBL3353410 | OSIMERTINIB | IC50 | = | 911.0 | nM | 6.04 |
| CHEMBL1173655 | AFATINIB | IC50 | = | 1401.0 | nM | 5.85 |
| CHEMBL4795165 | — | IC50 | = | 1570.0 | nM | 5.80 |
| CHEMBL4787483 | — | IC50 | = | 1675.0 | nM | 5.78 |
| CHEMBL4756368 | — | IC50 | = | 2236.0 | nM | 5.65 |
| CHEMBL554 | LAPATINIB | IC50 | = | 2685.0 | nM | 5.57 |
| CHEMBL180022 | NERATINIB | IC50 | = | 10117.0 | nM | 5.00 |