Assay Detail
Binding
CHEMBL4670985
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Binding affinity to human PD1-L1 (18-134 residues) expressed in Escherichia coli BL21 (DE3) incubated for 1 hr by MST analysis
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Di-bromo-Based Small-Molecule Inhibitors of the PD-1/PD-L1 Immune Checkpoint.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Kd | 3 | 8.14 | 8.49 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4765124 | — | — | 1 | 8.49 |
| CHEMBL4749472 | — | — | 1 | 8.40 |
| CHEMBL4071326 | — | — | 1 | 7.52 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4765124 | — | Kd | = | 3.2 | nM | 8.49 |
| CHEMBL4749472 | — | Kd | = | 4.0 | nM | 8.40 |
| CHEMBL4071326 | — | Kd | = | 30.3 | nM | 7.52 |