Assay Detail
Binding
CHEMBL4671578
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Binding affinity to human dopamine D1 receptor
25
Total Activities
25
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Synthesis and pharmacological evaluation of 11-(1,6-dimethyl-1,2,3,6-tetrahydropyridin-4-yl)-5H-dibenzo[b,e][1,4]diazepines with clozapine-like receptor occupancy at dopamine D/D receptor.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 25 | 8.33 | 9.89 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3039528 | ZICRONAPINE | 3.0 | 1 | 9.89 |
| CHEMBL4758723 | — | — | 1 | 9.70 |
| CHEMBL4756254 | — | — | 1 | 9.32 |
| CHEMBL298406 | ECOPIPAM | 3.0 | 1 | 9.05 |
| CHEMBL4795230 | — | — | 1 | 9.05 |
| CHEMBL4742056 | — | — | 1 | 8.96 |
| CHEMBL4760903 | — | — | 1 | 8.85 |
| CHEMBL4740880 | — | — | 1 | 8.80 |
| CHEMBL4745489 | — | — | 1 | 8.70 |
| CHEMBL4757297 | — | — | 1 | 8.70 |
| CHEMBL4745124 | — | — | 1 | 8.64 |
| CHEMBL4797375 | — | — | 1 | 8.62 |
| CHEMBL4758966 | — | — | 1 | 8.43 |
| CHEMBL4756987 | — | — | 1 | 8.40 |
| CHEMBL4776090 | — | — | 1 | 8.26 |
| CHEMBL4793813 | — | — | 1 | 8.10 |
| CHEMBL42 | CLOZAPINE | 4.0 | 1 | 7.36 |
| CHEMBL715 | OLANZAPINE | 4.0 | 1 | 7.33 |
| CHEMBL4779001 | — | — | 1 | 7.29 |
| CHEMBL4782694 | — | — | 1 | 7.26 |
| CHEMBL4748915 | — | — | 1 | 6.42 |
| CHEMBL4753299 | — | — | 1 | 6.11 |
| CHEMBL4745242 | — | — | 1 | - |
| CHEMBL4779083 | — | — | 1 | - |
| CHEMBL4784005 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3039528 | ZICRONAPINE | Ki | = | 0.13 | nM | 9.89 |
| CHEMBL4758723 | — | Ki | = | 0.2 | nM | 9.70 |
| CHEMBL4756254 | — | Ki | = | 0.48 | nM | 9.32 |
| CHEMBL298406 | ECOPIPAM | Ki | = | 0.9 | nM | 9.05 |
| CHEMBL4795230 | — | Ki | = | 0.9 | nM | 9.05 |
| CHEMBL4742056 | — | Ki | = | 1.1 | nM | 8.96 |
| CHEMBL4760903 | — | Ki | = | 1.4 | nM | 8.85 |
| CHEMBL4740880 | — | Ki | = | 1.6 | nM | 8.80 |
| CHEMBL4745489 | — | Ki | = | 2.0 | nM | 8.70 |
| CHEMBL4757297 | — | Ki | = | 2.0 | nM | 8.70 |
| CHEMBL4745124 | — | Ki | = | 2.3 | nM | 8.64 |
| CHEMBL4797375 | — | Ki | = | 2.4 | nM | 8.62 |
| CHEMBL4758966 | — | Ki | = | 3.7 | nM | 8.43 |
| CHEMBL4756987 | — | Ki | = | 4.0 | nM | 8.40 |
| CHEMBL4776090 | — | Ki | = | 5.5 | nM | 8.26 |
| CHEMBL4793813 | — | Ki | = | 7.9 | nM | 8.10 |
| CHEMBL42 | CLOZAPINE | Ki | = | 44.0 | nM | 7.36 |
| CHEMBL715 | OLANZAPINE | Ki | = | 47.0 | nM | 7.33 |
| CHEMBL4779001 | — | Ki | = | 51.0 | nM | 7.29 |
| CHEMBL4782694 | — | Ki | = | 55.0 | nM | 7.26 |
| CHEMBL4748915 | — | Ki | = | 380.0 | nM | 6.42 |
| CHEMBL4753299 | — | Ki | = | 780.0 | nM | 6.11 |
| CHEMBL4745242 | — | Ki | - | — | - | |
| CHEMBL4779083 | — | Ki | - | — | - | |
| CHEMBL4784005 | — | Ki | - | — | - |