Skip to main content
Free research Free research Free assay review with research home and workspace preview
Quick search ChEMBL 36
Assay Detail

CHEMBL4672126

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Binding affinity to human KEAP1 Kelch domain (322 to 609 residues) incubated for 60 mins by TR-FRET assay
ChEMBL ↗
72
Total Activities
72
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Homo sapiens
Confidence 9 — Direct single protein target
Curated By Autocuration

Target

Kelch-like ECH-associated protein 1 (CHEMBL2069156) ↗
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

Optimization of linear and cyclic peptide inhibitors of KEAP1-NRF2 protein-protein interaction.
Colarusso S,De Simone D,Frattarelli T,Andreini M,Cerretani M,Missineo A,Moretti D,Tambone S,Kempf G,Augustin M,Steinbacher S,Munoz-Sanjuan I,Park L,Summa V,Tomei L,Bresciani A,Dominguez C,Toledo-Sherman L,Bianchi E
Bioorg Med Chem (2020) 28 : 115738 -115738
PubMed 33065433 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 72 6.51 8.52

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL4747964 — — 1 8.52
CHEMBL4791554 — — 1 8.51
CHEMBL4764193 — — 1 8.47
CHEMBL4788971 — — 1 8.44
CHEMBL4747827 — — 1 8.38
CHEMBL4755277 — — 1 8.33
CHEMBL4790062 — — 1 8.32
CHEMBL4781886 — — 1 8.32
CHEMBL4740349 — — 1 8.13
CHEMBL4756743 — — 1 8.12
CHEMBL4762897 — — 1 8.00
CHEMBL4760303 — — 1 7.96
CHEMBL4792032 — — 1 7.96
CHEMBL4754176 — — 1 7.89
CHEMBL4794133 — — 1 7.80
CHEMBL4740544 — — 1 7.77
CHEMBL4746924 — — 1 7.72
CHEMBL4751630 — — 1 7.70
CHEMBL4788462 — — 1 7.62
CHEMBL4785277 — — 1 7.58
CHEMBL4750320 — — 1 7.52
CHEMBL4754751 — — 1 7.47
CHEMBL4785587 — — 1 7.36
CHEMBL4760005 — — 1 7.26
CHEMBL4756985 — — 1 7.26
CHEMBL4750619 — — 1 7.26
CHEMBL4776337 — — 1 7.16
CHEMBL4796106 — — 1 7.04
CHEMBL4778658 — — 1 7.04
CHEMBL4748504 — — 1 7.00

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL4747964 — IC50 = 3.0 nM 8.52
CHEMBL4791554 — IC50 = 3.1 nM 8.51
CHEMBL4764193 — IC50 = 3.4 nM 8.47
CHEMBL4788971 — IC50 = 3.6 nM 8.44
CHEMBL4747827 — IC50 = 4.2 nM 8.38
CHEMBL4755277 — IC50 = 4.7 nM 8.33
CHEMBL4790062 — IC50 = 4.8 nM 8.32
CHEMBL4781886 — IC50 = 4.8 nM 8.32
CHEMBL4740349 — IC50 = 7.4 nM 8.13
CHEMBL4756743 — IC50 = 7.5 nM 8.12
CHEMBL4762897 — IC50 = 10.0 nM 8.00
CHEMBL4760303 — IC50 = 11.0 nM 7.96
CHEMBL4792032 — IC50 = 11.0 nM 7.96
CHEMBL4754176 — IC50 = 13.0 nM 7.89
CHEMBL4794133 — IC50 = 16.0 nM 7.80
CHEMBL4740544 — IC50 = 17.0 nM 7.77
CHEMBL4746924 — IC50 = 19.0 nM 7.72
CHEMBL4751630 — IC50 = 20.0 nM 7.70
CHEMBL4788462 — IC50 = 24.0 nM 7.62
CHEMBL4785277 — IC50 = 26.0 nM 7.58
CHEMBL4750320 — IC50 = 30.0 nM 7.52
CHEMBL4754751 — IC50 = 34.0 nM 7.47
CHEMBL4785587 — IC50 = 44.0 nM 7.36
CHEMBL4750619 — IC50 = 55.0 nM 7.26
CHEMBL4760005 — IC50 = 55.0 nM 7.26
CHEMBL4756985 — IC50 = 55.0 nM 7.26
CHEMBL4776337 — IC50 = 70.0 nM 7.16
CHEMBL4796106 — IC50 = 91.0 nM 7.04
CHEMBL4778658 — IC50 = 91.0 nM 7.04
CHEMBL4748504 — IC50 = 101.0 nM 7.00
CHEMBL4759189 — IC50 = 107.3 nM 6.97
CHEMBL4787250 — IC50 = 115.0 nM 6.94
CHEMBL4750670 — IC50 = 166.0 nM 6.78
CHEMBL4793109 — IC50 = 180.0 nM 6.75
CHEMBL4749322 — IC50 = 192.0 nM 6.72
CHEMBL3134422 — IC50 = 193.0 nM 6.71
CHEMBL4747777 — IC50 = 207.0 nM 6.68
CHEMBL4752720 — IC50 = 280.0 nM 6.55
CHEMBL4743599 — IC50 = 430.0 nM 6.37
CHEMBL4778030 — IC50 = 486.0 nM 6.31
CHEMBL4777748 — IC50 = 1037.0 nM 5.98
CHEMBL4742010 — IC50 = 1594.0 nM 5.80
CHEMBL4786657 — IC50 = 1691.0 nM 5.77
CHEMBL4794380 — IC50 = 1765.0 nM 5.75
CHEMBL4762247 — IC50 = 4032.0 nM 5.39
CHEMBL4793306 — IC50 = 4302.0 nM 5.37
CHEMBL4779152 — IC50 = 4571.0 nM 5.34
CHEMBL4647979 — IC50 = 5878.0 nM 5.23
CHEMBL4779325 — IC50 = 6062.0 nM 5.22
CHEMBL4752836 — IC50 = 6076.0 nM 5.22