Assay Detail
Binding
CHEMBL4672269
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of EGFR-TK (unknown origin) relative to control
10
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
New series of isoxazole derivatives targeting EGFR-TK: Synthesis, molecular modeling and antitumor evaluation.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 10 | 7.05 | 7.27 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4751362 | — | — | 1 | 7.27 |
| CHEMBL4740108 | — | — | 1 | 7.19 |
| CHEMBL4755651 | — | — | 1 | 7.18 |
| CHEMBL553 | ERLOTINIB | 4.0 | 1 | 7.17 |
| CHEMBL1619395 | — | — | 1 | 7.09 |
| CHEMBL4755988 | — | — | 1 | 7.09 |
| CHEMBL1545480 | — | — | 1 | 6.97 |
| CHEMBL4776730 | — | — | 1 | 6.91 |
| CHEMBL4787698 | — | — | 1 | 6.84 |
| CHEMBL4751085 | — | — | 1 | 6.82 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4751362 | — | IC50 | = | 54.0 | nM | 7.27 |
| CHEMBL4740108 | — | IC50 | = | 64.0 | nM | 7.19 |
| CHEMBL4755651 | — | IC50 | = | 66.0 | nM | 7.18 |
| CHEMBL553 | ERLOTINIB | IC50 | = | 67.0 | nM | 7.17 |
| CHEMBL1619395 | — | IC50 | = | 81.0 | nM | 7.09 |
| CHEMBL4755988 | — | IC50 | = | 81.0 | nM | 7.09 |
| CHEMBL1545480 | — | IC50 | = | 106.0 | nM | 6.97 |
| CHEMBL4776730 | — | IC50 | = | 124.0 | nM | 6.91 |
| CHEMBL4787698 | — | IC50 | = | 144.0 | nM | 6.84 |
| CHEMBL4751085 | — | IC50 | = | 150.0 | nM | 6.82 |