Assay Detail
Binding
CHEMBL4672512
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of rat lens ALR2 using D,L-glyceraldehyde as substrate preincubated for 5 mins at 30 degC followed by substrate addition and measured after 4 mins in presence of NADPH
15
Total Activities
15
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Tissue | Lens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Aldo-keto reductase family 1 member B1 (CHEMBL2622) ↗| Type | SINGLE PROTEIN |
| Organism | Rattus norvegicus |
Publication
Dihydrobenzoxazinone derivatives as aldose reductase inhibitors with antioxidant activity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 15 | 6.52 | 7.35 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL56337 | EPALRESTAT | 4.0 | 1 | 7.35 |
| CHEMBL4764862 | — | — | 1 | 7.09 |
| CHEMBL4744605 | — | — | 1 | 6.86 |
| CHEMBL4762576 | — | — | 1 | 6.78 |
| CHEMBL4755765 | — | — | 1 | 6.77 |
| CHEMBL4759527 | — | — | 1 | 6.73 |
| CHEMBL4761601 | — | — | 1 | 6.68 |
| CHEMBL4758298 | — | — | 1 | 6.66 |
| CHEMBL4789112 | — | — | 1 | 6.58 |
| CHEMBL4747536 | — | — | 1 | 6.55 |
| CHEMBL4796974 | — | — | 1 | 6.51 |
| CHEMBL4740716 | — | — | 1 | 6.11 |
| CHEMBL4761076 | — | — | 1 | 5.98 |
| CHEMBL4758428 | — | — | 1 | 5.71 |
| CHEMBL4745147 | — | — | 1 | 5.48 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL56337 | EPALRESTAT | IC50 | = | 45.0 | nM | 7.35 |
| CHEMBL4764862 | — | IC50 | = | 82.0 | nM | 7.09 |
| CHEMBL4744605 | — | IC50 | = | 138.0 | nM | 6.86 |
| CHEMBL4762576 | — | IC50 | = | 167.0 | nM | 6.78 |
| CHEMBL4755765 | — | IC50 | = | 170.0 | nM | 6.77 |
| CHEMBL4759527 | — | IC50 | = | 188.0 | nM | 6.73 |
| CHEMBL4761601 | — | IC50 | = | 208.0 | nM | 6.68 |
| CHEMBL4758298 | — | IC50 | = | 220.0 | nM | 6.66 |
| CHEMBL4789112 | — | IC50 | = | 262.0 | nM | 6.58 |
| CHEMBL4747536 | — | IC50 | = | 281.0 | nM | 6.55 |
| CHEMBL4796974 | — | IC50 | = | 308.0 | nM | 6.51 |
| CHEMBL4740716 | — | IC50 | = | 774.0 | nM | 6.11 |
| CHEMBL4761076 | — | IC50 | = | 1050.0 | nM | 5.98 |
| CHEMBL4758428 | — | IC50 | = | 1932.0 | nM | 5.71 |
| CHEMBL4745147 | — | IC50 | = | 3340.0 | nM | 5.48 |