Skip to main content
Free research Free research Free assay review with research home and workspace preview
Quick search ChEMBL 36
Assay Detail

CHEMBL4672541

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Binding affinity to N-terminal GST tagged human ATAD2B (953-1085 residues) expressed in Escherichia coli by ITC analysis
20
Total Activities
20
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Homo sapiens
Confidence 9 — Direct single protein target
Curated By Autocuration

Target

ATPase family AAA domain-containing protein 2B (CHEMBL2176775)
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

Structural Insights into the Recognition of Mono- and Diacetylated Histones by the ATAD2B Bromodomain.
Lloyd JT,McLaughlin K,Lubula MY,Gay JC,Dest A,Gao C,Phillips M,Tonelli M,Cornilescu G,Marunde MR,Evans CM,Boyson SP,Carlson S,Keogh MC,Markley JL,Frietze S,Glass KC
J Med Chem (2020) 63 : 12799 -12813
PubMed 33084328 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
Kd 20 4.80 6.78

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL3590405 1 6.78
CHEMBL4786330 1 5.28
CHEMBL4748520 1 4.73
CHEMBL4792431 1 4.55
CHEMBL4794843 1 4.46
CHEMBL4748267 1 4.45
CHEMBL4751427 1 4.37
CHEMBL4750026 1 4.32
CHEMBL4762063 1 4.30
CHEMBL4748867 1 -
CHEMBL4781561 1 -
CHEMBL4743832 1 -
CHEMBL4761046 1 -
CHEMBL4762443 1 -
CHEMBL4757518 1 -
CHEMBL4790258 1 -
CHEMBL4795500 1 -
CHEMBL4797943 1 -
CHEMBL4751374 1 -
CHEMBL4778442 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL3590405 Kd = 166.9 nM 6.78
CHEMBL4786330 Kd = 5200.0 nM 5.28
CHEMBL4748520 Kd = 18700.0 nM 4.73
CHEMBL4792431 Kd = 28100.0 nM 4.55
CHEMBL4794843 Kd = 34400.0 nM 4.46
CHEMBL4748267 Kd = 35700.0 nM 4.45
CHEMBL4751427 Kd = 42500.0 nM 4.37
CHEMBL4750026 Kd = 48000.0 nM 4.32
CHEMBL4762063 Kd = 50500.0 nM 4.30
CHEMBL4748867 Kd - -
CHEMBL4781561 Kd - -
CHEMBL4743832 Kd - -
CHEMBL4761046 Kd - -
CHEMBL4762443 Kd = 213900.0 nM -
CHEMBL4757518 Kd - -
CHEMBL4790258 Kd - -
CHEMBL4795500 Kd = 685300.0 nM -
CHEMBL4797943 Kd - -
CHEMBL4751374 Kd = 1164200.0 nM -
CHEMBL4778442 Kd - -