Skip to main content
Free research Free research Free assay review with research home and workspace preview
Quick search ChEMBL 36
Assay Detail

CHEMBL4672964

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Inhibition of Kca3.1 in human erythrocytes
10
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Homo sapiens
Confidence 9 — Direct single protein target
Curated By Autocuration

Publication

Novel Potassium Channel Inhibitors.
Blass BE.
ACS Med Chem Lett (2020) 11 : 2357 -2358
PubMed 33335651 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 10 7.62 8.09

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL4744833 1 8.09
CHEMBL4749039 1 8.07
CHEMBL4791725 1 8.06
CHEMBL4788143 1 7.85
CHEMBL4756080 1 7.75
CHEMBL4764429 1 7.62
CHEMBL4745327 1 7.33
CHEMBL4743839 1 7.28
CHEMBL4780941 1 7.12
CHEMBL4785936 1 7.04

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL4744833 IC50 = 8.1 nM 8.09
CHEMBL4749039 IC50 = 8.6 nM 8.07
CHEMBL4791725 IC50 = 8.7 nM 8.06
CHEMBL4788143 IC50 = 14.0 nM 7.85
CHEMBL4756080 IC50 = 18.0 nM 7.75
CHEMBL4764429 IC50 = 24.0 nM 7.62
CHEMBL4745327 IC50 = 47.0 nM 7.33
CHEMBL4743839 IC50 = 52.0 nM 7.28
CHEMBL4780941 IC50 = 75.0 nM 7.12
CHEMBL4785936 IC50 = 92.0 nM 7.04