Compound Detail
CHEMBL4744833
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Basic Information
| ChEMBL ID | CHEMBL4744833 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | QSACBKBMELRLBA-CYBMUJFWSA-N |
1
Targets
1
Activities
1
Assay Types
0
PK Parameters
1
Publications
0
Known Names
Molecular Properties
374.4
MW (Da)
4.00
ALogP
3
HBA
0
HBD
32.8
PSA (Ų)
0.75
QED
0
Ro5 Violations
4
Rot. Bonds
Drug Information
| Molecule Type | Unknown |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 1 meas. best 8.09
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Intermediate conductance calcium-activated potassium channel protein 4 CHEMBL4305 | IC50 | 8.09 | 8.09 | 8.1 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Intermediate conductance calcium-activated potassium channel protein 4 | IC50 | = | 8.1 | nM | 8.09 | Inhibition of Kca3.1 in human erythrocytes | 33335651 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 33335651 | 10.1021/acsmedchemlett.0c00569 | Intermediate conductance calcium-activated potassium channel protein 4 | 1 |
Data from ChEMBL 36 via Core Engine