Assay Detail
Binding
CHEMBL4672965
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Protac binding affinity at CRBN/BCR-ABL (unknown origin) assessed as binding to phosphorylated c-ABL kinase domain by Kinomescan assay
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 5 — Multiple protein complex / RNA |
| Curated By | Autocuration |
Target
Protein cereblon/BCR/ABL (CHEMBL4296137) ↗| Type | PROTEIN-PROTEIN INTERACTION |
| Organism | Homo sapiens |
Publication
Breakthrough in Degradation of BCR-ABL Fusion Protein for the Treatment of Cancer.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Kd | 5 | 9.65 | 9.96 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4748640 | — | — | 1 | 9.96 |
| CHEMBL4742867 | — | — | 1 | 9.89 |
| CHEMBL4747034 | — | — | 1 | 9.64 |
| CHEMBL4642168 | — | — | 1 | 9.49 |
| CHEMBL4742759 | — | — | 1 | 9.26 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4748640 | — | Kd | = | 0.11 | nM | 9.96 |
| CHEMBL4742867 | — | Kd | = | 0.13 | nM | 9.89 |
| CHEMBL4747034 | — | Kd | = | 0.23 | nM | 9.64 |
| CHEMBL4642168 | — | Kd | = | 0.32 | nM | 9.49 |
| CHEMBL4742759 | — | Kd | = | 0.55 | nM | 9.26 |