Assay Detail
Functional
CHEMBL4673733
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antitrypanosomal activity against bloodstream form of Trypanosoma brucei rhodesiense STIB900 incubated for 70 hrs by Alamar blue dye-based fluorometric analysis
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Trypanosoma brucei rhodesiense |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Target
Trypanosoma brucei rhodesiense (CHEMBL612348) ↗| Type | ORGANISM |
| Organism | Trypanosoma brucei rhodesiense |
Publication
Investigation of thiazolyl-benzothiophenamides as potential agents for African sleeping sickness
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 5.57 | 7.85 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL166 | MELARSOPROL | 3.0 | 1 | 7.85 |
| CHEMBL4761032 | — | — | 1 | 5.30 |
| CHEMBL4785398 | — | — | 1 | 5.15 |
| CHEMBL4751801 | — | — | 1 | 5.06 |
| CHEMBL4741937 | — | — | 1 | 5.05 |
| CHEMBL4786148 | — | — | 1 | 4.98 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL166 | MELARSOPROL | IC50 | = | 14.0 | nM | 7.85 |
| CHEMBL4761032 | — | IC50 | = | 5040.0 | nM | 5.30 |
| CHEMBL4785398 | — | IC50 | = | 7130.0 | nM | 5.15 |
| CHEMBL4751801 | — | IC50 | = | 8680.0 | nM | 5.06 |
| CHEMBL4741937 | — | IC50 | = | 8960.0 | nM | 5.05 |
| CHEMBL4786148 | — | IC50 | = | 10580.0 | nM | 4.98 |